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Surface plasmon resonance

Applications in understanding receptor-ligand interaction

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Abstract

During last decade there has been significant progress in the development of analytical techniques for evaluation of receptor-ligand iteraction. Surface plasmon resonance (SPR)-based optical biosensors are now being used extensively to defined the kinetics of wide variety of macromolecular interactions and high- and low-affinity small molecule interactions. The experimental design data analysis methods are evolving along with widespread applications in ligand fishing, microbiology, virology, host-pathogen interaction, epitope mapping and protein-, cell-, membrane-, nucleic acid-protein interactions. SPR based biosensors have strong impact on basic and applied research significantly. This brief review describes the SPR technology and few of its applications in relation to receptor-ligand interaction that has brought significant change in the methodology, analysis, interpretation, and application of the SPR technology.

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Authors and Affiliations

  1. Virology Division, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India

    Priyabrata Pattnaik

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  1. Priyabrata Pattnaik
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Pattnaik, P. Surface plasmon resonance. Appl Biochem Biotechnol 126, 79–92 (2005). https://doi.org/10.1385/ABAB:126:2:079

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  • DOI: https://doi.org/10.1385/ABAB:126:2:079

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