Applications of polymer nanofibers in biomedicine and biotechnology
- 1.7k Downloads
Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and internal molecular structures. A wide range of biodegradable biopolymers can be electrospun into mats with specific fiber arrangement and structural integrity. Through secondary processing, the nanofiber surface can be functionalized to display specific biochemical characteristics. It is hypothesized that the large surface area of nanofibers with specific surface chemistry facilitates attachment of cells and control of their cellular functions. These features of nanofiber mats are morphologically and chemically similar to the extracellular matrix of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, effective mechanical properties, and specific biochemical properties. The current emphasis of research is on exploiting such properties and focusing on determining appropriate conditions for electrospinning various polymers and biopolymers for eventual applications including multifunctional membranes, biomedical structural elements (scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, vascular grafts), protective shields in specialty fabrics, and filter media for submicron particles in the separation industry. This has resulted in the recent applications for polymer nanofibers in the field of biomedicine and biotechnology.
Index EntriesElectrospinning nanofibers tissue engineering biotechnology scaffolds
Unable to display preview. Download preview PDF.
- 9.Schreuder-Gibson, H., Gibson, P., Ziegler, D., and Tsai, P. P. (2002), J. Adv. Mater. 34, 44–55.Google Scholar
- 12.Hickman, K. (2002), www.csa.com. Date accessed: March 21, 2005.Google Scholar
- 13.Smith, D.J., Reneker, D.M., McManus, A.T. Schreuder-Gibson, H.L., Mello, C., and Sennett, M.S. (2004), The University of Akron, US Patent 6753454.Google Scholar
- 17.Miller, M. and Evans, G. R. (1998), in Frontiers in Tissue Engineering, Patrick, C. W., Mikos, A. G., and McIntire, L. V., eds., Pergamon, New York, pp. 213–232.Google Scholar
- 26.Bowlin, G. L. (2003), www.futurepundit.com.Google Scholar
- 28.Robins, B. D. (1992), Br. J. Theatre Nurs. 12, 9–12.Google Scholar
- 36.Freed, L. E., Rupnick, M. A., Schaefer, D., and Vunjak-Novakovic (2003) in Functional Tissue Engineering: The Role of Biomechanics, Guilak, F., Butler, D., Mooney, D., and Goldstein, S., eds., Springer Verlag, pp. 360–376.Google Scholar
- 47.Kikuchi, M., Cho, S. B., and Tanaka, J. (1997), Bioceramics 10, 407–410.Google Scholar
- 51.Thomson, R. C., Shung, A. K., and Mikos, A. G. (2000), in Principles of Tissue Engineering, Lanza, R. P., Langer, R., Vacanti, J. P., eds., Academic, San Diego, pp. 251–261.Google Scholar