Obesity Surgery

, Volume 15, Issue 7, pp 1024–1029 | Cite as

Sleeve Gastrectomy and Gastric Banding: Effects on Plasma Ghrelin Levels

  • F B Langer
  • M A Reza Hoda
  • A Bohdjalian
  • F X Felberbauer
  • J Zacherl
  • E Wenzl
  • K Schindler
  • A Luger
  • B Ludvik
  • G Prager
Article

Background: Different changes of plasma ghrelin levels have been reported following gastric banding, Roux-en-Y gastric bypass, and biliopancreatic diversion. Methods: This prospective study compares plasma ghrelin levels and weight loss following laparoscopic sleeve gastrectomy (LSG) and laparoscopic adjustable gastric banding (LAGB) in 20 patients. Results: Patients who underwent LSG (n=10) showed a significant decrease of plasma ghrelin at day 1 compared to preoperative values (35.8 ± 12.3 fmol/ml vs 109.6 ± 32.6 fmol/ml, P=0.005). Plasma ghrelin remained low and stable at 1 and 6 months postoperatively. In contrast, no change of plasma ghrelin at day 1 (71.8 ± 35.3 fmol/ml vs 73.7 ± 24.8 fmol/ml, P=0.441) was found in patients after LAGB (n=10). Increased plasma ghrelin levels compared with the preoperative levels at 1 (101.9 ± 30.3 fmol/ml vs 73.7 ± 24.8 fmol/ml, P=0.028) and 6 months (104.9 ± 51.1 fmol/ml vs 73.7 ± 24.8 fmol/ml, P=0.012) after surgery were observed. Mean excess weight loss was higher in the LSG group at 1 (30 ± 13% vs 17 ± 7%, P=0.005) and 6 months (61 ± 16% vs 29 ± 11%, P=0.001) compared with the LAGB group. Conclusions: As a consequence of resection of the gastric fundus, the predominant area of human ghrelin production, ghrelin is significantly reduced after LSG but not after LAGB. This reduction remains stable at follow-up 6 months postoperatively, which may contribute to the superior weight loss when compared with LAGB.

MORBID OBESITY GHRELIN SLEEVE GASTRECTOMY GASTRIC BANDING 

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Copyright information

© Springer 2005

Authors and Affiliations

  • F B Langer
    • M A Reza Hoda
      • A Bohdjalian
        • F X Felberbauer
          • J Zacherl
            • E Wenzl
              • K Schindler
                • A Luger
                  • B Ludvik
                    • G Prager

                      There are no affiliations available

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