Advertisement

Obesity Surgery

, Volume 11, Issue 6, pp 693–698 | Cite as

Serum Leptin Levels After Bariatric Surgery Across a Range of Glucose Tolerance from Normal to Diabetes

  • Bruno Geloneze
  • Marcos Antonio Tambascia
  • Enrico Maluf Repetto
  • Sandra Grandim Pereira
  • José Carlos Pareja
  • Luis Alberto Magna
Article

Background: A longitudinal, clinical intervention study with bariatric surgery was done to investigate the relationship between leptin levels, BMI, and insulin during weight loss across a range of glucose tolerance from normal to diabetes. Methods: 43 morbidly obese patients (BMI: 42-75 kg/m2) undergoing vertical banded gastroplasty Roux-en-Y gastric bypass (VBG-RGB), were divided into 3 groups: 21 normal (NGT), 12 impaired glucose tolerance (IGT) and 10 type 2 diabetes (DM). Leptin, insulin, glucose, lipids and uric acid were measured at baseline and 2, 4, 6, and 12 months following surgery. Results: BMI fell from 54.1 ± 9.1 to 34.6 ± 6.3 kg/m2, similarly in all groups. Leptin decreased from 73.9 ± 8.7 to 16.9 ± 10.2 ng/ml and was strongly correlated with BMI during 1-year follow-up (r=0.78; p<0.001). Linear univariate analysis for repeated evaluation showed a positive correlation between leptin and glucose, triglycerides, uric acid, and insulin. Multivariate regression analysis indicated that BMI was independently correlated with the decrease in leptin (p<0.001), accounting for 66% of the variance in leptin levels during weight loss. These results were found in the NGT and IGT groups. In the DM group, a small additional influence in leptin levels was attributed to glucose decrease. Conclusions: A strong link between leptin and BMI was found after surgery. BMI was the main determinant of the decrease of leptin. In these patients submitted to bariatric surgery, ranging from normal glucose tolerance to diabetes, changes in insulin levels and metabolic parameters, except for glucose in the DM group, did not appear to be correlated with changes in leptin levels.

BARIATRIC SURGERY MORBID OBESITY INSULIN LEPTIN 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer 2001

Authors and Affiliations

  • Bruno Geloneze
    • Marcos Antonio Tambascia
    • Enrico Maluf Repetto
    • Sandra Grandim Pereira
    • José Carlos Pareja
    • Luis Alberto Magna

    There are no affiliations available

    Personalised recommendations