A new method has been developed for the determination of metalaxyl, myclobutanil, and tebuconazole in environmental water samples with preconcentration by cartridges packed with SiO2 microspheres prior to LC. Several parameters such as the volume and composition of eluent, sample flow rate, sample pH, and sample volume were optimized. Under the optimal conditions, excellent detection limits (S/N = 3) and precision (RSD, n = 6) were 0.02 ng mL−1, 1.3% for metalaxyl, 0.02 ng mL−1, and 2.4% for myclobutanil and 0.08 ng mL−1 and 4.3% for tebuconazole, respectively. The method was applied to the analysis of real-water samples, and satisfactory results were obtained. The average spiked recoveries were in the range of 86.3–97.5%. These results indicate that SiO2 microspheres have great potential to be used as a novel solid phase extraction adsorbent that could have wide applications in the environmental field.
Column liquid chromatography Preconcentration on SiO2 microspheres Metalaxyl, myclobutanil and tebuconazole Water samples
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This work was supported by the Personal Innovation Foundation of Universities in Henan Province [(2005)126], the fund from State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (No. KF2009-16) and Natural Science Foundation of Henan Province (082300430340).