Skip to main content
SpringerLink
Log in

Comparative Pharmacokinetics Profile of Vasa Swaras with Vasicine and Vasicinone

  • Original
  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

An RP-LC method was developed and validated for comparing the pharmacokinetics profile of Vasa Swaras (leaf juice of Adhatoda vasica Nees., Fam. Acanthaceae) with that of the pure vasicine and vasicinone (chief marker compounds of A. vasica) upon oral administration of Vasa Swaras in rats, and also in different animal groups. Significant difference with p < 0.05 was found in the oral bioavailability of vasicine and vasicinone when administered as Vasa Swaras and as single vasicine and/or vasicinone. Vasicine and vasicinone were found to be more bioavailable from Vasa Swaras than pure vasicine and/or vasicinone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Claeson UP, Malmfors T, Wikman G, Bruhn JG (2000) J Ethnopharmacol 72:1–20. doi:10.1016/S0378-8741(00)00225-7

    Article  CAS  Google Scholar 

  2. The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products (1948). Council of Scientific and Industrial Research, New Delhi, pp 31–32

  3. Sharma PV (1996) Classical Uses of Medicinal Plants, 1st edn. Chaukhambha Visvabharti, Varanasi, pp 340–343

    Google Scholar 

  4. Dymock W, Waeden CJH, Hooper D (1890) Pharmacographia Indica: A History of the Principal Drugs of Vegetable Origin. Paul, Trech, Trubner & Co. Ltd, London, pp 50–54

    Google Scholar 

  5. Wakhloo RL, Wakhloo D, Gupta OP, Atal CK (1979) J Obste Gynaecol 29:939–940

    CAS  Google Scholar 

  6. Doshi JJ, Patel VK, Bhatt HV (1983) Int J Crude Drug Res 21:173–176

    Google Scholar 

  7. Mathew AS, Patel KN, Shah BK (1998) J Nat Prod 14:11–16

    Google Scholar 

  8. Dhuley JN (1999) J Ethnopharmacol 67:361–365. doi:10.1016/S0378-8741(99)00074-4

    Article  CAS  Google Scholar 

  9. Indian Herbal Pharmacopoeia (2002) Indian Drug Manufacturing Association, Mumbai, pp 33-39

  10. Gupta OP, Sharma ML, Ghataka BJR, Atal CK (1977) Indian J Med Res 66:680–691

    CAS  Google Scholar 

  11. Bhide MB, Naik PY, Ghooi RB (1976) Bull Haffkin Ins 4:45–50

    Google Scholar 

  12. Sharma PC, Yelne MB, Dennis TJ (2000) Database on Medicinal Plants used in Ayurveda (Vol. I). Central Council of Research in Ayurveda and Siddha, New Delhi, pp 496–509

    Google Scholar 

  13. Ram HNA, Shirwaikar A (2007) Pharmacologyonline 2:53–60

    Google Scholar 

  14. Amla V, Bano G, Johri RK, Zutshi U, Atal CK (1987) Zhongguo Yao Li Xue Bao 8:190–192

    CAS  Google Scholar 

  15. Sharma A, Lal K, Handa SS (1992) Pharm Biol 30:205–208. doi:10.3109/13880209209053998

    Article  CAS  Google Scholar 

  16. Brain KR, Thapa BB (1983) J Chromatgr 258:183–188

    Article  CAS  Google Scholar 

  17. Chowdhuri BK, Hirani SK (1987) J Chromatogr 390:439–443

    Article  Google Scholar 

  18. Srivastava S, Verma RK, Gupta MM, Singh SC, Kumar S (2001) J Liq Chrom & Rel Technol 24:153–159. doi:10.1081/JLC-100001478

    Article  CAS  Google Scholar 

  19. Das C, Poi R, Chowdhury A (2005) Phytochem Anal 16:90–92. doi:10.1002/pca.817

    Article  CAS  Google Scholar 

  20. Rajani M, Pundarikakshudu K (1996) Pharm Biol 34:308–309. doi:10.1076/phbi.34.4.308.13227

    Article  CAS  Google Scholar 

  21. Brahmanada T (2001) Saranghdhar Samhita. Chaukhambha Surbharti Prakashan, Varanasi, pp 125–132

    Google Scholar 

  22. Pahwa GS, Zutshi U, Atal CK (1987) Indian J Exp Biol 25:467–470

    CAS  Google Scholar 

  23. Chowdhury BK (1987) Indian J Chem B 26:688–689

    Google Scholar 

Download references

Acknowledgments

The authors wish to acknowledge NIPER – Ahmedabad for their grant as Junior Research Scholarship to Mr. Ranjeet Prasad Dash to carry out this work and J.B Chemicals, Mumbai, India for providing metronidazole as gift sample.

Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, S. G. Highway, Thaltej, Ahmedabad, 380054, Gujarat, India

    Ranjeet Prasad Dash, Bhupendrasinh F. Chauhan & Manish Nivsarkar

  2. Department of Natural Products, National Institute of Pharmaceutical Education and Research-Ahmedabad, S. G. Highway, Thaltej, Ahmedabad, 380054, Gujarat, India

    Sheetal Anandjiwala

Authors
  1. Ranjeet Prasad Dash
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bhupendrasinh F. Chauhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sheetal Anandjiwala
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Manish Nivsarkar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Manish Nivsarkar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dash, R.P., Chauhan, B.F., Anandjiwala, S. et al. Comparative Pharmacokinetics Profile of Vasa Swaras with Vasicine and Vasicinone. Chroma 71, 609–615 (2010). https://doi.org/10.1365/s10337-010-1517-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1365/s10337-010-1517-x

Keywords

Search

Navigation