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Investigations on the Influence of Interface-Geometry in CE-ESI-TOF-MS

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Abstract

Three different interfaces for the coupling of capillary electrophoresis with electrospray time-of-flight mass spectrometry are compared with respect to major parameters like sensitivity or robustness. The separation and detection of a test mixture of nine fluoroquinolones was employed for evaluation of these interfaces. Besides a commercially available orthogonal sheath-flow interface, an in-lab constructed in-axis sheath-flow interface (tested in two different geometrical alignments) and a simple lab-made sheathless interface were investigated. Crucial parameters like limits of detection achieved as well as ease of operation and robustness were monitored.

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Authors and Affiliations

  1. Institute of Analytical Chemistry, Johannes-Kepler-University, Altenbergerstrasse 69, 4040, Linz, Austria

    Silke M. Reiter, Wolfgang Buchberger & Christian W. Klampfl

Authors
  1. Silke M. Reiter
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  2. Wolfgang Buchberger
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  3. Christian W. Klampfl
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Correspondence to Christian W. Klampfl.

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Reiter, S.M., Buchberger, W. & Klampfl, C.W. Investigations on the Influence of Interface-Geometry in CE-ESI-TOF-MS. Chroma 71, 715–719 (2010). https://doi.org/10.1365/s10337-010-1504-2

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  • DOI: https://doi.org/10.1365/s10337-010-1504-2

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