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CE Enantioseparation of Betti Bases with Cyclodextrins and Crown Ether as Chiral Selectors

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Abstract

Direct capillary zone electrophoretic methods were developed for the separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol and 2-(α-aminoarylmethyl)-1-naphthol analogues. The effects of selector and buffer concentrations, electrolyte pH and applied voltage on the separation efficiency were studied. Variation of the electrophoretic conditions with the application of negative polarity, hydrodynamic injection, an unmodified silica capillary, different buffers and sulfated cyclodextrins and (S,S)-dimethylpyridino-18-crown-6 ether as chiral selectors led to the baseline resolution of all the compounds investigated.

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Acknowledgment

This work was supported by OTKA grants K 67563 and K 62654, and by Jedlik Ányos grant 00180/2007, NKFP_07_A3_NATURSEP.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, 6720, Szeged, Hungary

    István Ilisz, Zoltán Pataj & Antal Péter

  2. CycloLab R&D Ltd, Illatos út 7, 1097, Budapest, Hungary

    Róbert Iványi

  3. Department of Organic Chemistry and Technology, Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, PO Box 91, 1521, Budapest, Hungary

    József Kupai & Péter Huszthy

  4. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, 6720, Szeged, Hungary

    István Szatmári & Ferenc Fülöp

Authors
  1. István Ilisz
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  2. Róbert Iványi
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  3. Zoltán Pataj
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  4. József Kupai
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  5. Péter Huszthy
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  6. István Szatmári
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  7. Ferenc Fülöp
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  8. Antal Péter
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Correspondence to István Ilisz.

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Dedicated to Professor Károly Lempert on the occasion of his 85th birthday.

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Ilisz, I., Iványi, R., Pataj, Z. et al. CE Enantioseparation of Betti Bases with Cyclodextrins and Crown Ether as Chiral Selectors. Chroma 71 (Suppl 1), 115–119 (2010). https://doi.org/10.1365/s10337-009-1465-5

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  • DOI: https://doi.org/10.1365/s10337-009-1465-5

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