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Chromatographic Application on Calixarene Bonded Stationary Phases: A Stability Indicating LC-Method for Determination of Celecoxib in Tablet Formulation

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Abstract

A method is described for extraction and quantification of celecoxib in tablets. The extraction was achieved through centrifugation of the fine powder of the tablets in Acetonitrile (ACN). The extract was examined by LC. The chromatographic separation was carried out on a Caltrex AIII column, a relatively new packing material consisting of silica-bonded calix[8]arene, using isocratic binary mobile phase of ACN and H2O (55%:45%, v/v). A diode array detector was used at 254 nm for detection. The method was validated for system suitability, linearity, precision, limits of detection and quantitation, specificity, stability and robustness. The limits of detection and quantitation were 0.122 and 0.488 μg mL−1, respectively. The recovery value of this method was 101.88% and the reproducibility was within 2.08.

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Acknowledgment

We thank Syntrex GbR (Greifswald, Germany) for supplying the calixarene column.

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Authors and Affiliations

  1. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

    Hisham Hashem

  2. Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Ernst-Moritz-Arndt-University Greifswald, F.-L.-Jahn-Str. 17, 17487, Greifswald, Germany

    Clemens Tründelberg & Thomas Jira

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  1. Hisham Hashem
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  2. Clemens Tründelberg
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  3. Thomas Jira
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Correspondence to Thomas Jira.

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Hashem, H., Tründelberg, C. & Jira, T. Chromatographic Application on Calixarene Bonded Stationary Phases: A Stability Indicating LC-Method for Determination of Celecoxib in Tablet Formulation. Chroma 71, 91–94 (2010). https://doi.org/10.1365/s10337-009-1400-9

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  • DOI: https://doi.org/10.1365/s10337-009-1400-9

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