Abstract
A new class of chiral stationary phases (CSP) with peptide chiral selectors was prepared by solid-phase synthesis with a tert-butoxycarbonyl-L-amino acid on silica. The type of amino acid that is favorable for this class of CSP is discussed. Using the CSP with the phenylalanine peptide selector, the effect of peptide length on the enantioselectivity was investigated in normal-phase mode. The applicability of the CSP with a phenylalanine peptide to chiral ligand-exchange chromatography was also examined.
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Acknowledgment
The authors thank Daiso Co., Ltd. (Osaka) for the kind gift of 3-aminopropyl silyl silica gel.
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Ohyama, K., Oyamada, K., Kishikawa, N. et al. Investigation of Novel Peptide Chiral Selectors Prepared by Solid-Phase Synthesis with a tert-Butoxycarbonyl Amino Acid. Chroma 70, 1501–1504 (2009). https://doi.org/10.1365/s10337-009-1345-z
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DOI: https://doi.org/10.1365/s10337-009-1345-z