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A Simple and Sensitive Analytical Method for Determination of Naltrexone Level in Plasma by GC–MS

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Abstract

A gas chromatography-mass spectrometry method for determination of naltrexone in plasma is presented. The method is based on pre-column derivatization of analyte to trimethylsilyl derivative of naltrexone. The analyte and internal standard were extracted from plasma by liquid–liquid extraction. Validation of the method has been studied in the concentration range 1–50 ng mL−1.

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References

  1. O’Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992) Arch Gen Psychiatry 49(11):881–887

    Google Scholar 

  2. Yoburn BC, Cohen AH, Inturrisi CE (1986) J Pharmacol Exp Ther 237(1):126–130

    CAS  Google Scholar 

  3. Kranzler HR, Modesto-Lowe V, Nuwayser ES (1998) Alcohol Clin Exp Res 22(5):1074–1079

    CAS  Google Scholar 

  4. Nelson CC, Fraser MD, Wilfahrt JK, Foltz RL (1993) Ther Drug Monit 15(6):557–562. doi:10.1097/00007691-199312000-00019

    Article  CAS  Google Scholar 

  5. Verebey K, Alarazi J, Lehrer M, Mule SJ (1986) Chromatogr B 378(1):261–266. doi:10.1016/S0378-4347(00)80723-9

    Article  CAS  Google Scholar 

  6. Sams RA, Malspeis L (1976) Chromatograph 125(2):409–420. doi:10.1016/S0021-9673(00)83372-5

    Article  CAS  Google Scholar 

  7. Burce GL, Bhat HB, Sokoloski T (1977) J Chromatogr A 137(2):323–332. doi:10.1016/S0021-9673(00)81355-2

    Article  CAS  Google Scholar 

  8. Reuning RH, Batra VK, Ludden TM (1979) J Pharm Sci 68(4):411–416. doi:10.1002/jps.2600680405

    Article  CAS  Google Scholar 

  9. Verebey K, De Pace A, Jukofsky D (1980) J Anal Toxicol 4(1):33–37

    CAS  Google Scholar 

  10. Slawson MH, Chen M, Moody D, Comer SD, Nuwayser E, Fang WB, Foltz R (2007) J Anal Toxicol 31(8):453–461

    CAS  Google Scholar 

  11. Monti KM, Foltz RL, Chinn DM (1991) J Anal Toxicol 15(3):136–140

    CAS  Google Scholar 

  12. Huang W, Moody DE, Foltz RL, Walsh SL (1997) J Anal Toxicol 21(4):252–257

    CAS  Google Scholar 

  13. Derendorf H, El Koussi AE, Garrett ER (1984) J Pharm Sci 73(5):621–624. doi:10.1002/jps.2600730510

    Article  CAS  Google Scholar 

  14. Hurst WJ, Zagon IS, Aboul-Enein HY (1999) Pharmazie 54(8):595–596

    CAS  Google Scholar 

  15. Zuccaro P, Altieri I, Betto P, Pacifici R, Ricciarello G, Pini LA, Sternieri E, Pichini S (1991) J Chromatogr B Analyt Technol Biomed Life Sci 567(2):485–490

    CAS  Google Scholar 

  16. Peh KK, Billa N, Yuen KH (1997) J Chromatogr B Analyt Technol Biomed Life Sci 701(1):140–145. doi:10.1016/S0378-4347(97)00352-6

    Article  CAS  Google Scholar 

  17. Hunter RP, Koch DE, Mutlow A, Isaza R (2003) J Chromatogr B Analyt Technol Biomed Life Sci 793(2):351–355. doi:10.1016/S1570-0232(03)00351-9

    Article  CAS  Google Scholar 

  18. Kambia K, Bah S, Dine T, Azar R, Odou P, Gressier B, Luyckx M, Cazin JC (2000) Biomed Chromatogr 14(3):151–155. doi:10.1002/1099-0801(200005)14:3<151:AID-BMC941>3.0.CO;2-E

    Article  CAS  Google Scholar 

  19. Dinarvand R, Moghadam SH, Sayar P, Alaee M, Atyabi F (2005) Therapy 2(3):407–413. doi:10.2217/14750708.2.3.407

    Article  CAS  Google Scholar 

  20. Moody DE, Monti KM, Spanbauer AC, Hsu JP (1999) J Anal Toxicol 23(6):535–540

    CAS  Google Scholar 

  21. Meyer MC, Straughn AB, Lo MW (1984) J Clin Psychiatry 45:15–19

    CAS  Google Scholar 

  22. Ferrari A, Bertolotti M, Dell’Utri A, Avico U, Sternieri E (1998) Drug Alcohol Depend 52(3):211–220. doi:10.1016/S0376-8716(98)00098-2

    Article  CAS  Google Scholar 

  23. Meatherall R (1999) J Anal Toxicol 23(3):177–186

    CAS  Google Scholar 

  24. Davidson AF, Emm TA, Pieniaszek HJ Jr (1996) J Pharm Biomed Anal 14(12):1717–1725. doi:10.1016/0731-7085(96)01794-3

    Article  CAS  Google Scholar 

  25. Toennes SW, Kauert GF, Grüsser SM, Jäkel W, Partecke G (2004) J Pharm Biomed Anal 35(1):169–176. doi:10.1016/j.jpba.2004.01.013

    Article  CAS  Google Scholar 

  26. Abdi K, Shafiee A, Amini M, Ghazi-Khansari M, Sabzevari O (2004) DARU 12(2):71–75

    CAS  Google Scholar 

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Acknowledgment

This study was supported by grant no. NRCI-5982 of the National Research Projects and with the support of the National Research Council of Islamic Republic of Iran.

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, 14155-6451, Tehran, Iran

    Rezaei Mehrdad, Dinarvand Rassoul & Vosough-Ghanabri Sanaz

  2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, 14155-6451, Tehran, Iran

    Abdi Khosrou & Amini Mohsen

  3. Drug Design & Development Research Center, Tehran University of Medical Sciences, 14155-645, Tehran, Iran

    Amini Mohsen

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  1. Rezaei Mehrdad
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  2. Abdi Khosrou
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  3. Dinarvand Rassoul
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  4. Vosough-Ghanabri Sanaz
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Correspondence to Amini Mohsen.

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Mehrdad, R., Khosrou, A., Rassoul, D. et al. A Simple and Sensitive Analytical Method for Determination of Naltrexone Level in Plasma by GC–MS. Chroma 70, 1491–1494 (2009). https://doi.org/10.1365/s10337-009-1309-3

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  • DOI: https://doi.org/10.1365/s10337-009-1309-3

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