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Validated Stability-Indicating Chromatographic Methods for the Determination of Veralipride in Presence of Its Degradation Products

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Abstract

Two sensitive and selective chromatographic methods were developed and validated for determination of veralipride in presence of its degradation products. Forced degradation studies were performed, using HCl, NaOH and 3% H2O2. The first method is based on thin-layer chromatographic separation of the intact drug spot from its degradation, followed by densitometric measurements. The second method is based on isocratic liquid chromatographic separation of the studied drug from its degradation on a reversed phase C18 column. The proposed LC method was utilized to investigate the kinetics of alkaline degradation process of the selected drug at different temperatures.

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Authors and Affiliations

  1. Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Maissa Yacoub Salem & Laila El-Sayed Abdel Fattah

  2. National Organization for Drug Control and Research (NODCAR), 6 Abou Hazem Street, Pyramids, P.O. Box 29, Cairo, Egypt

    Nahla Nour El Din Salama & Lobna Mohammed Abd El Halim

Authors
  1. Maissa Yacoub Salem
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  2. Nahla Nour El Din Salama
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  3. Lobna Mohammed Abd El Halim
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  4. Laila El-Sayed Abdel Fattah
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Corresponding author

Correspondence to Lobna Mohammed Abd El Halim.

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Salem, M.Y., Salama, N.N.E.D., Halim, L.M.A.E. et al. Validated Stability-Indicating Chromatographic Methods for the Determination of Veralipride in Presence of Its Degradation Products. Chroma 70, 1299–1302 (2009). https://doi.org/10.1365/s10337-009-1302-x

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  • DOI: https://doi.org/10.1365/s10337-009-1302-x

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