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Pressurized Liquid Extraction Coupled with LC–ESI–MS–MS for the Determination of Herbicides Chlormequat and Mepiquat in Flours

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Abstract

This paper describes a new method for the rapid extraction and unequivocal confirmation of herbicides chlormequat and mepiquat in wheat flours and various flours utilized in infant foods. The highly automated extraction procedure is based on accelerated solvent extraction, followed by liquid chromatography-tandem mass spectrometry as a confirmatory analysis. Typical recoveries from flours and baby food samples ranged from 83 to 99% at a fortification level of 10 ppb, corresponding to the maximum residue limits established by the European Union; while relative standard deviations (RSD) were less than 10% for all samples. The limit of detection (signal-to-noise ratio = 3) of the method for the considered phenols in baby food samples are less than 0.1 μg g−1. Traces of the selected herbicides have been detected in about 50% of baby foods, bought from different Roman supermarkets and butcher shops, applying the described methodology.

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Authors and Affiliations

  1. Laboratorio Chimico per la Sicurezza, Università “La Sapienza” di Roma, Rome, Italy

    Stefano Marchese & Daniela Perret

  2. Dipartimento di Chimica, Università “La Sapienza” di Roma, Piazzale Aldo Moro no 5, P.O. Box 34, Posta 62, 00185, Rome, Italy

    Stefano Marchese, Eleonora Bafile, Alessandra Gentili, Fulvia Caretti & Marco Berardino

Authors
  1. Stefano Marchese
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  2. Daniela Perret
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  3. Eleonora Bafile
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  4. Alessandra Gentili
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  5. Fulvia Caretti
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  6. Marco Berardino
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Correspondence to Stefano Marchese.

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Marchese, S., Perret, D., Bafile, E. et al. Pressurized Liquid Extraction Coupled with LC–ESI–MS–MS for the Determination of Herbicides Chlormequat and Mepiquat in Flours. Chroma 70, 761–767 (2009). https://doi.org/10.1365/s10337-009-1266-x

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  • DOI: https://doi.org/10.1365/s10337-009-1266-x

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