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Direct TLC Resolution of the Enantiomers of Three β-Blockers by Ligand Exchange with Cu(II)–l-Amino Acid Complex, Using Four Different Approaches

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Abstract

TLC experiments have been performed to resolve the enantiomers of three β-blockers by complexation chiral TLC with Cu(II) cation and five l amino acids. Loading was carried out by using the Cu(II)–l amino acid complex as chiral mobile phase additive with untreated silica gel plates; by mixing the Cu complex with silica gel before preparing the TLC plates; by ascending development of untreated plates with solutions of the Cu complex; and by using a solution of Cu(II) acetate as mobile phase additive for plates prepared by mixing the l amino acid with silica gel. Spots were located by use of iodine vapour.

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Acknowledgments

Thanks are due to the University Grants Commission (UGC) for award of a senior research fellowship to S.T.

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  1. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India

    Ravi Bhushan & Shivani Tanwar

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  1. Ravi Bhushan
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  2. Shivani Tanwar
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Correspondence to Ravi Bhushan.

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Bhushan, R., Tanwar, S. Direct TLC Resolution of the Enantiomers of Three β-Blockers by Ligand Exchange with Cu(II)–l-Amino Acid Complex, Using Four Different Approaches. Chroma 70, 1001–1006 (2009). https://doi.org/10.1365/s10337-009-1216-7

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  • DOI: https://doi.org/10.1365/s10337-009-1216-7

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