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Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection

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Abstract

A highly sensitive and selective method for determination of histamine in rat plasma and tissue extracts by liquid chromatography with fluorescence detection is described. The method is based on precolumn derivatization of amino groups of histamine with two molecules of 4-(1-pyrene)butyric acid N-hydroxysuccinimide ester that allows generation of intramolecular excimer fluorescence. The detection limit for histamine was 0.183 nM. This sensitivity allowed determination of histamine in 10 μL of rat plasma or in the extracts from less than 1 mg of tissue.

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Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 14572043) from the Ministry of Education, Science, Sports and Culture of Japan, and Advanced Materials Institute, Fukuoka University.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka, 814-0180, Japan

    Fumio Ichinose, Hideyuki Yoshida, Kenichiro Todoroki, Hitoshi Nohta & Masatoshi Yamaguchi

  2. Chemicals Evaluation and Research Institute, 3-822 Ishii Machi, Hita, Oita, 877-0061, Japan

    Fumio Ichinose

  3. Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, 171 77, Stockholm, Sweden

    Takashi Yoshitake & Jan Kehr

  4. School of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan

    Takashi Yoshitake

  5. Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Osamu Inoue

Authors
  1. Fumio Ichinose
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  2. Takashi Yoshitake
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  3. Hideyuki Yoshida
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  4. Kenichiro Todoroki
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  5. Jan Kehr
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  6. Osamu Inoue
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  7. Hitoshi Nohta
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  8. Masatoshi Yamaguchi
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Corresponding author

Correspondence to Masatoshi Yamaguchi.

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Ichinose, F., Yoshitake, T., Yoshida, H. et al. Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection. Chroma 70, 575–580 (2009). https://doi.org/10.1365/s10337-009-1162-4

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  • DOI: https://doi.org/10.1365/s10337-009-1162-4

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