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Separation of Clinical Grade 188Re from 188W Using Polymer Embedded Nanocrystalline Titania

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Abstract

Currently, 188Re is obtained from 188W/188Re chromatographic generator containing alumina which has a limited capacity (~80 mg Wg−1) for 188W. This results in high bolus volumes of 188Re, which often needs to be concentrated before radiolabeling. We have demonstrated the feasibility of using polymer embedded nano crystalline titania (TiP), a novel high capacity sorbent material (~300 mg Wg−1), for developing a 188W/188Re chromatographic generator. A TiP based chromatographic 188W/188Re generator was developed in which 188Re could be eluted with 0.9% saline solution. About 90% of the 188Re could be recovered in the first 4–5 mL of total activity with more than 80% yield. The purity of 188Re is adequate for clinical applications.

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Acknowledgments

The authors are grateful to Dr. V. Venugopal, Director, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre for his support to this program. The authors wish to acknowledge Dr. V.K. Manchanda, Head, Radiochemistry Division and Dr. S. Ray, Head, Uranium Extraction Division of this centre for providing their facilities for the determination of zeta potential and ICP analyses respectively.

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  1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, 400085, India

    Rubel Chakravarty, Ashutosh Dash & Meera Venkatesh

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  1. Rubel Chakravarty
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  2. Ashutosh Dash
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  3. Meera Venkatesh
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Correspondence to Ashutosh Dash.

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Chakravarty, R., Dash, A. & Venkatesh, M. Separation of Clinical Grade 188Re from 188W Using Polymer Embedded Nanocrystalline Titania. Chroma 69, 1363–1372 (2009). https://doi.org/10.1365/s10337-009-1070-7

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  • DOI: https://doi.org/10.1365/s10337-009-1070-7

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