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A Validated RP-LC Method for Advanced Intermediate of Rabeprazole Sodium

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Abstract

The present paper describes the development of a reversed phase liquid chromatographic method for advanced intermediate of rabeprazole sodium (RBS-1) in the presence of its impurities. Successful separation of RBS-1 from the synthetic impurities achieved on a Inertsil ODS3V C18, 150 mm × 4.6 mm column. The developed LC method was validated with respect to linearity, accuracy, precision, specificity and ruggedness. To the best of our knowledge, a validated stability indicating LC method which separates all the impurities disclosed in this investigation was not published elsewhere.

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Acknowledgment

The authors would like to thank all the colleagues of the R&D Department, Inogent Laboratories Private Ltd., Hyderabad, India, for their support to carry out this investigation.

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Authors and Affiliations

  1. Analytical Development Laboratory, Inogent Laboratories Private Limited, No. 28A, IDA, Nacharam, Hyderabad, 500 076, India

    Koduri S. V. Srinivas & Polisetty Srinivasulu

  2. Research & Development Laboratory, Inogent Laboratories Private Limited, No. 28A, IDA, Nacharam, Hyderabad, 500 076, India

    Reguri Buchireddy

  3. Centre for Environment, JNT University, Kukatpally, Hyderabad, 500 072, India

    Koduri S. V. Srinivas, Khagga Mukkanti & Polisetty Srinivasulu

Authors
  1. Koduri S. V. Srinivas
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  2. Reguri Buchireddy
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  3. Khagga Mukkanti
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  4. Polisetty Srinivasulu
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Corresponding author

Correspondence to Koduri S. V. Srinivas.

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Srinivas, K.S.V., Buchireddy, R., Mukkanti, K. et al. A Validated RP-LC Method for Advanced Intermediate of Rabeprazole Sodium. Chroma 69, 381–384 (2009). https://doi.org/10.1365/s10337-008-0902-1

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  • DOI: https://doi.org/10.1365/s10337-008-0902-1

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