Skip to main content

Advertisement

SpringerLink
Log in

Application of Multicriteria Methodology in the Development of Improved RP-LC-DAD for Determination of Rizatriptan and Its Degradation Products

  • Original
  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

The aim of this study was to establish an improved isocratic RP-LC-DAD method for separation and determination of rizatriptan benzoate and its two degradation products, L-749.019 and L-783.540 in tablets. Since the chromatographic behavior of target substances can be influenced by various experimental parameters, the whole study was carried out by employing experimental design methodology. The investigation included the influence of mutual changes of the mobile phase composition (methanol amount in the range 3–7% and pH of the water phase from 5.0 to 6.0) and the temperature (from 20 to 30 °C). The response surface design by means of Box-Brehnken design was used to obtain a predictive model which describes the changes in the response within the experimental domain. Additionally, several different target responses were evaluated and Derringer’s desirability function was used for reaching a suitable compromise among the responses. This multi-criteria decision making approach is based on constructing a desirability function for each individual response and afterwards establishing the overall desirability function. Such methodology provided us with the best operating conditions, satisfactory resolutions between the analytes and the shortest possible total analysis time. The experiments were performed on C18 XTerra (150 mm × 3.9 mm), 5 μm column with the mobile phase consisting of a mixture of methanol, TEA and 0.01 mol L−1 KH2PO4 (6:9.4:84.6 v/v) pumped at a flow rate of 1.2 mL min−1, pH of the water phase adjusted to 6 with 85% orthophosphoric acid, a column temperature of 20 °C and detection at 225 nm. Afterwards, the new method was validated and subsequently applied in analysis of commercially available rizatriptan tablets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Oldman AD, Smith LA, McQuay HS, Moore RA (2002) Pain 97:247–257. doi:10.1016/S0304-3959(02)00024-6

    Article  CAS  Google Scholar 

  2. Gori S, Morelli N, Bellini G, Bonanni E, Manca L, Orlandi G et al (2005) Brain Res Bull 65:297–300. doi:10.1016/j.brainresbull.2004.10.015

    Article  CAS  Google Scholar 

  3. Williamson DJ, Shepheard SL, Hill RG, Hargreaves RJ (1997) Eur J Pharmacol 328:61–64. doi:10.1016/S0014-2999(97)83028-2

    Article  CAS  Google Scholar 

  4. ICH Q3B(R2) (2003), revision included (2006) Fed Regist 68: 64628–64629

  5. ICH Q3A(R2) (2003), revision included (2006) Fed Regist 68: 6924–6925

  6. Mallikarjuna Rao B, Sangaraju S, Srinivasu MK, Madhavan P, Devi ML, Kumar PR (2006) J Pharm Biomed Anal 41:1146–1151. doi:10.1016/j.jpba.2006.02.026

    Article  CAS  Google Scholar 

  7. Mahuzie P, Clark BJ, Crumpton AJ, Altria KD (2001) J Sep Sci 24:784–788. doi:10.1002/1615-9314(20010901)24:9<784::AID-JSSC784>3.0.CO;2-2

    Article  Google Scholar 

  8. Altinoz S, Ucar G, Yıldız E (2002) Anal Lett 35:2471–2485. doi:10.1081/AL-120016538

    Article  CAS  Google Scholar 

  9. Chen J, Jiang X, Jiang W, Mei N, Gao X, Zhang Q (2004) J Chromatogr B Analyt Technol Biomed Life Sci 805:169–173. doi:10.1016/j.jchromb.2004.02.021

    Article  CAS  Google Scholar 

  10. McLoughlin DA, Olah TV, Ellis JD, Gilbert JD, Halpin RA (1996) J Chromatogr A 726:115–124. doi:10.1016/0021-9673(96)88660-2

    Article  CAS  Google Scholar 

  11. Barrish A, Olah TV, Gatto GJ, Dobrinska MR, Gilbert JD (1996) Rapid Commun Mass Spectrom 10:1033–1037. doi:10.1002/(SICI)1097-0231(19960715)10:9<1033::AID-RCM616>3.0.CO;2-4

    Article  CAS  Google Scholar 

  12. Vishwanathan K, Bartlett MG, Stewart JT (2000) Rapid Commun Mass Spectrom 14:168–172. doi:10.1002/(SICI)1097-0231(20000215)14:3<168::AID-RCM861>3.0.CO;2-9

    Article  CAS  Google Scholar 

  13. Chen J, Jiang XG, Jiang WM, Gao XL, Mei N (2005) Pharmazie 60:39–41

    CAS  Google Scholar 

  14. Musson DG, Birk KL, Panebianco DL, Gagliano KD, Rogers JD, Goldberg MR (2001) Int J Clin Pharmacol Ther 39:447–452

    CAS  Google Scholar 

  15. Lee Y, Conroy JA, Stepanavage ME, Mandel CM, Somers G, McLoughlin DA et al (1999) J Clin Pharmacol 47:373–378. doi:10.1046/j.1365-2125.1999.00917.x

    Article  CAS  Google Scholar 

  16. Vincent A, Lisa W, Pascal T (1998) J Liquid Chromatogr Relat Technol 21:1649–1670. doi:10.1080/10826079808001250

    Article  Google Scholar 

  17. Jocic B, Zecevic M, Zivanovic L, Licanski A (2007) Anal Lett 40:2301–2316. doi:10.1080/00032710701575959

    Article  CAS  Google Scholar 

  18. Candioti LV, Robles J, Mantovani V, Goicoechea H (2006) Talanta 69:140–147. doi:10.1016/j.talanta.2005.09.021

    Article  CAS  Google Scholar 

  19. Sivakumar T, Manavalan R, Muralidharan C, Valliappan K (2007) J Pharm Biomed Anal 43:1842–1848. doi:10.1016/j.jpba.2006.12.007

    Article  CAS  Google Scholar 

  20. Rueda ME, Sarabia LA, Herrero A, Ortiz MC (2003) Anal Chim Acta 479:173–184. doi:10.1016/S0003-2670(02)01542-8

    Article  CAS  Google Scholar 

  21. Cruz Ortiz M, Herrero A, Sanllorente S, Reguera C (2005) Talanta 65:246–254

    Google Scholar 

  22. Safa F, Hadjmohammadi MR (2005) J Chromatogr A 1078:42–50. doi:10.1016/j.chroma.2005.04.081

    Article  CAS  Google Scholar 

  23. Gfrerer M, Lankmayr E (2005) Anal Chim Acta 533:203–211. doi:10.1016/j.aca.2004.11.016

    Article  CAS  Google Scholar 

  24. Stafiej A, Pyrzynska K, Ranz A, Lankmayr E (2006) J Biochem Biophys Methods 69:15–24. doi:10.1016/j.jbbm.2006.02.009

    Article  CAS  Google Scholar 

  25. Martendal E, Budziak D, Carasek E (2007) J Chromatogr A 1148:131–136. doi:10.1016/j.chroma.2007.02.079

    Article  CAS  Google Scholar 

  26. Mirza T, Tan H (2001) J Pharm Biomed Anal 25:39–52. doi:10.1016/S0731-7085(00)00462-3

    Article  CAS  Google Scholar 

  27. Preu M, Guyot D, Petz M (1998) J Chromatogr A 818:95–108. doi:10.1016/S0021-9673(98)00537-8

    Article  CAS  Google Scholar 

  28. Hows M, Perrett D, Kay J (1997) J Chromatogr A 768:97–104. doi:10.1016/S0021-9673(97)00107-6

    Article  CAS  Google Scholar 

  29. Chopra S, Patil G, Motwani S (2007) Eur J Pharm Biopharm 66:73–82. doi:10.1016/j.ejpb.2006.09.001

    Article  CAS  Google Scholar 

  30. Ragonese R, Macka M, Hughes J, Petocz P (2002) J Pharm Biomed Anal 27:995–1007. doi:10.1016/S0731-7085(01)00659-8

    Article  CAS  Google Scholar 

  31. Orwa JA, Vandenbempt K, Depuydt S, Roets E, Hoogmartens J (1999) J Pharm Biomed Anal 20:745–752. doi:10.1016/S0731-7085(99)00043-6

    Article  CAS  Google Scholar 

  32. Nowak M, Seubert A (1999) J Chromatogr A 855:91–109. doi:10.1016/S0021-9673(99)00683-4

    Article  CAS  Google Scholar 

  33. Zeaiter M, Roger JM, Bellon-Maurel V, Rutledge DN (2004) Trends Analyt Chem 23:157–170. doi:10.1016/S0165-9936(04)00307-3

    Article  CAS  Google Scholar 

  34. Lundstedt T, Seifert E, Abramo L, Thelin B, Nystrom A, Pettersen J et al (1998) Chemom Intell Lab Syst 42:3–40. doi:10.1016/S0169-7439(98)00065-3

    Article  CAS  Google Scholar 

  35. ICH Q2(R1) (1997) addendum incorporated (2005). Fed Regist 62:27463–27467

Download references

Acknowledgments

This research was supported by the Ministry of Science and Environmental Protection of the Republic of Serbia as the part of the project “Synthesis, Quantitative Structure/Properties and Activity Relationship, Physical-Chemical Characterization and Analysis of Pharmacologically Active Substances” No. 142071 B.

Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Institute of Pharmaceutical Chemistry and Drug Analysis, Vojvode Stepe 450, 11152, Belgrade, Serbia

    Mira Zečević, Biljana Jocić, Ljiljana Živanović & Ana Protić

Authors
  1. Mira Zečević
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Biljana Jocić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ljiljana Živanović
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ana Protić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mira Zečević.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zečević, M., Jocić, B., Živanović, L. et al. Application of Multicriteria Methodology in the Development of Improved RP-LC-DAD for Determination of Rizatriptan and Its Degradation Products. Chroma 68, 911–918 (2008). https://doi.org/10.1365/s10337-008-0823-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1365/s10337-008-0823-z

Keywords

Search

Navigation