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LC and Principal Component Analysis in the Lipophilicity Study of Seven Angiotensin II-AT1 Receptor Antagonists (Sartans)

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Abstract

Seven sartans have been chromatographed with acetonitrile-buffer and methanol–buffer in different proportions as mobile phases. The retention values, log k or R M were extrapolated to zero organic modifier content to obtain the log k w or R MW values. Calibration equations were obtained for standards of known lipophilicity. A simple method employing a gradient procedure of 10–100% acetonitrile or methanol in 60 min and standards of the extreme lipophilicity was also elaborated. Chromatographic log P values were compared to those calculated by use of different software products. Finally, principal component analysis was performed to explore and visualize similarities and differences among the drugs and among the methods.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego Str. 4, 20-090, Lublin, Poland

    Tadeusz Inglot, Anna Gumieniczek, Łukasz Komsta & Agata Kasińska

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  1. Tadeusz Inglot
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  2. Anna Gumieniczek
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  3. Łukasz Komsta
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  4. Agata Kasińska
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Correspondence to Anna Gumieniczek.

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Inglot, T., Gumieniczek, A., Komsta, Ł. et al. LC and Principal Component Analysis in the Lipophilicity Study of Seven Angiotensin II-AT1 Receptor Antagonists (Sartans). Chroma 68, 977–983 (2008). https://doi.org/10.1365/s10337-008-0801-5

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  • DOI: https://doi.org/10.1365/s10337-008-0801-5

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