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LC Assay of Eletriptan in Tablets and In Vitro Dissolution Studies

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Abstract

Eletriptan (ELT) is a new selective serotonin agonist approved for the treatment of acute migraine headaches. A simple and rapid liquid chromatographic method was developed and validated for the assay of ELT in tablets. Chromatography was carried out on a 250 mm × 4.6 mm C18 column at 30 °C. Acetonitrile–15 mM triethylamine solution (adjusted to pH 7.0 using concentrated o-phosphoric acid) (60:40, v/v) mixture was used as mobile phase at 1.0 mL min−1 flow rate and UV detector was set at 225 nm. A linear response (r 2 = 0.9999) was observed in the range of 0.1–1.6 μg mL−1. The method showed good recoveries (100.08 %) and the RSD values for intra- and inter-day precision were 0.78–1.93 and 1.10–2.15%, respectively. The method can be used for quality control assays and in vitro dissolution studies of ELT in tablets.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul University, 34116, Istanbul, Turkey

    Olcay Sagirli & Armağan Önal

  2. Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, 34116, Istanbul, Turkey

    Demet Şensoy

Authors
  1. Olcay Sagirli
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  2. Armağan Önal
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  3. Demet Şensoy
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Correspondence to Olcay Sagirli.

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Sagirli, O., Önal, A. & Şensoy, D. LC Assay of Eletriptan in Tablets and In Vitro Dissolution Studies. Chroma 68, 269–273 (2008). https://doi.org/10.1365/s10337-008-0673-8

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  • DOI: https://doi.org/10.1365/s10337-008-0673-8

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