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Simultaneous Determination of Fluoroquinolones and Sulfonamides in Chicken Muscle by LC with Fluorescence and UV Detection

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Abstract

A simple, rapid and sensitive liquid chromatographic method with programmable fluorescence and ultraviolet detection was developed and validated for simultaneous determination of seven fluoroquinolones (marbofloxacin, ofloxacin, ciprofloxacin, lomefloxacin, danofloxacin, enrofloxacin and difloxacin) and four sulfonamides (sulfadiazine, sulfapyridine, sulfathiazole and sulfadimidine) in chicken muscle in a single run. The tissue sample was extracted with phosphate buffer (pH 6.0) and cleaned-up with a solid phase extraction cartridge. The mean recoveries for each drug in chicken muscle ranged from 78.0 to 105.2% with a relative standard deviation below 9.3% at 0.2–400 ng g−1 fortification levels. The limit of quantification was 0.2–4.0 ng g−1 for fluoroquinolones and 15.0 ng g−1 for sulfonamides.

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Acknowledgments

The National Science Fund for Distinguished Young Scholars of China (No. 30325032) and CAU Scientific Research Foundation (No. 2007026) provided financial supports for this work.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People’s Republic of China

    Cun Li, Hai-Yang Jiang, Si-Jun Zhao, Su-Xia Zhang, Shuang-Yang Ding, Jian-Cheng Li, Xiao-Wei Li & Jian-Zhong Shen

  2. National Reference Laboratories for Veterinary Drug Residue, District Haidian, Beijing, 100094, People’s Republic of China

    Hai-Yang Jiang, Su-Xia Zhang, Shuang-Yang Ding, Jian-Cheng Li, Xiao-Wei Li & Jian-Zhong Shen

  3. Department of Veterinary Medicine, College of Agriculture, Hebei University of Engineering, Handan, 056038, People’s Republic of China

    Cun Li

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  1. Cun Li
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Correspondence to Jian-Zhong Shen.

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Li, C., Jiang, HY., Zhao, SJ. et al. Simultaneous Determination of Fluoroquinolones and Sulfonamides in Chicken Muscle by LC with Fluorescence and UV Detection. Chroma 68, 117–121 (2008). https://doi.org/10.1365/s10337-008-0664-9

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  • DOI: https://doi.org/10.1365/s10337-008-0664-9

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