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System Maps for RP-LC on an Octadecylsiloxane-Bonded Silica Stationary Phase (SunFire C18)

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Abstract

The solvation parameter model is used to elucidate the retention mechanism of neutral organic compounds on the octadecylsiloxane-bonded silica stationary phase SunFire C18 with acetonitrile–water, methanol–water and tetrahydrofuran–water mobile phases containing from 10 to 70% (v/v) organic solvent. The dominant factors that increase retention are solute size and electron lone pair interactions while polar interactions reduce retention. The contribution of solvent type on selectivity is discussed in relation to its affect on the system constants of the solvation parameter model. Steric repulsion is shown not to affect the retention mechansim for a wide range of compounds and electrostatic interactions are shown to be weak and only important for mobile phases containing acetonitrile. Dewetting affects the retention mechanism of acetonitrile–water mobile phase compositions containing less than 30% (v/v) acetonitrile and for tetrahydrofuran–water compositions containing less than 20% (v/v) tetrahydrofuran. SunFire C18 should be suitable for determining the S, A and B solute descriptors for neutral compounds and weak bases using reversed-phase liquid chromatography.

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Authors and Affiliations

  1. Flint Group North America, Analytical and Physical Sciences Laboratory, 1130 James L Hart Parkway, Ypsilanti, MI, 48197, USA

    Waruna Kiridena & Wladyslaw W. Koziol

  2. Department of Chemistry, Rm 183, Wayne State University, Detroit, MI, 48202, USA

    Sanka N. Atapattu & Colin F. Poole

Authors
  1. Waruna Kiridena
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  2. Sanka N. Atapattu
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  3. Colin F. Poole
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  4. Wladyslaw W. Koziol
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Corresponding author

Correspondence to Colin F. Poole.

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Kiridena, W., Atapattu, S.N., Poole, C.F. et al. System Maps for RP-LC on an Octadecylsiloxane-Bonded Silica Stationary Phase (SunFire C18). Chroma 68, 11–17 (2008). https://doi.org/10.1365/s10337-008-0644-0

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  • DOI: https://doi.org/10.1365/s10337-008-0644-0

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