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Selective LC Determination of Cabergoline in the Bulk Drug and in Tablets: In Vitro Dissolution Studies

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Abstract

Cabergoline (CAB) is an ergot alkaloid derivative with dopamine agonist activity. A novel, simple, and rapid stability-indicating high-performance liquid chromatographic (HPLC) method for assay of CAB in tablets has been developed and validated. Chromatography was performed on a 4.6 mm i.d. × 250 mm, 5 μm particle, cyano column with acetonitrile–10 mM phosphoric acid, 35:65 (v/v), containing 0.04% triethylamine, as mobile phase, at a flow rate of 1.0 mL min−1, and UV detection at 280 nm. Response was a linear function of concentration in the range 0.1–4 μg mL−1 (r 2 = 0.9999). The recovery of the method was good (99.45%) and RSD values for intra-day and inter-day precision were 0.24–0.88% and 0.66–1.19%, respectively. The method can be used for quality-control assay of CAB in tablets, for stability studies, and for in vitro dissolution studies.

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Acknowledgments

The author (A.Onal) would like to thank the Research Fund of Istanbul University for support of this work (Project numbers: UDP-902/31012007).

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul University, 34116, Istanbul, Turkey

    A. Önal & O. Sağırlı

  2. Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, 34116, Istanbul, Turkey

    D. Şensoy

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  1. A. Önal
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  2. O. Sağırlı
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  3. D. Şensoy
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Correspondence to A. Önal.

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Önal, A., Sağırlı, O. & Şensoy, D. Selective LC Determination of Cabergoline in the Bulk Drug and in Tablets: In Vitro Dissolution Studies. Chroma 65, 561–567 (2007). https://doi.org/10.1365/s10337-007-0211-0

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  • DOI: https://doi.org/10.1365/s10337-007-0211-0

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