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Separation and Recognition of the Enantiomers of trans Arylcyclopropanecarboxylic Acids and their Amide and Nitrile Derivatives on Polysaccharide Stationary Phases

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Abstract

Separation of the enantiomers of several trans arylcyclopropanecarboxylic acids and their amide and nitrile derivatives has been systematically studied on three polysaccharide HPLC stationary phases, amylose tris-(3,5-dimethylphenylcarbamate), cellulose tris-(3,5-dimethylphenylcarbamate), and cellulose tris-(4-methylbenzoate). Enantiomer recognition by the chiral stationary phases is discussed in terms of the type of functional group, electronic and steric effects of substituents on the analytes, the structure of the chiral stationary phase, and mobile phase composition.

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Acknowledgement

We thank the State Major Fundamental Research Program (2003CB716005), the National Science Foundation of China, the Chinese Academy of Sciences, and the Center for Molecular Science for financial support.

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Correspondence to D.-X. Wang or M.-X. Wang.

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Wang, D., Zhang, X., Zhang, J. et al. Separation and Recognition of the Enantiomers of trans Arylcyclopropanecarboxylic Acids and their Amide and Nitrile Derivatives on Polysaccharide Stationary Phases. Chroma 65, 343–348 (2007). https://doi.org/10.1365/s10337-006-0161-y

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Keywords

  • Column liquid chromatography
  • Enantiomer recognition and separation
  • Polysaccharide stationary phase
  • trans Arylcyclopropanecarboxylic acids, amides, and nitriles