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LC Determination of Clonidine Hydrochloride in Chinese and Western Combine Compound Hypotensor Tablets of Zhenju Jiangya

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Abstract

A new method has been developed to determine clonidine hydrochloride in Zhenju Jiangya Tablets using ion-pair HPLC coupled with neutral column chromatography in this paper. Clonidine hydrochloride is an active component and occurs in very low amounts. The sample was purified by neutral Al2O3 column chromatography instead of liquid–liquid extraction and measured by reversed phase ion-pair chromatography with 1-heptanesulfonate at acidic pH with UV-detection. Result showed that clonidine hydrochloride had good linearity in the range of 1.1–11.0 μg mL−1 (r = 0.9993) and the average recoveries were 96.5–99.3% (RSD 2.1–4.8%).

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Authors and Affiliations

  1. Department of Chemical Engineering, Shandong Institute of Light Industry, Jinan, Shandong, 250100, China

    Ying-Qin Wei & Yi Ma

  2. School of Chemistry and Chemical Engineering of Shandong University (east campus), Shandong, Jinan, 250100, China

    Hua-Bin Zou

  3. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong, Jinan, 250014, China

    Jiu-Rong Yuan

Authors
  1. Ying-Qin Wei
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  2. Hua-Bin Zou
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  3. Yi Ma
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  4. Jiu-Rong Yuan
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Correspondence to Ying-Qin Wei.

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Wei, YQ., Zou, HB., Ma, Y. et al. LC Determination of Clonidine Hydrochloride in Chinese and Western Combine Compound Hypotensor Tablets of Zhenju Jiangya. Chroma 64, 215–218 (2006). https://doi.org/10.1365/s10337-006-0011-y

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  • DOI: https://doi.org/10.1365/s10337-006-0011-y

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