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Detection of Several Classes of Pesticides and Metabolites in Meconium by Gas Chromatography-Mass Spectrometry

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Abstract

A solid phase extraction method was developed to isolate multiple classes of parent pesticides from meconium. A methanolic/hydrochloric acid methyl ester derivatization with liquid-liquid extraction technique was also developed for the analysis of metabolites. Identification and quantitation was by electron impact gas chromatography-mass spectrometry. For the parent compounds and metabolites, recoveries in spiked meconium ranged between 72–109%, with coefficients of variation ranging from 1.55–16.92% and limits of detection between 0.01– 4.15 µg g−1. Meconium samples obtained from infants in the Philippines were assayed using these methods, and propoxur, cypermethrin, pretilachlor, malathion, 4,4′-dichlorodiphenyltrichloroethylene, bioallethrin, and cyfluthrin were detected.

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Authors and Affiliations

  1. Department of Pediatrics, Wayne State University School of Medicine, 421 E. Canfield Blvd., Rm. 2245, 48201, MI, Detroit, USA

    D. Bielawski, E. Ostrea Jr., N. Posecion Jr., M. Corrion & J. Seagraves

  2. Institute of Child Health and Human Development, University of the Philippines, Manila, Philippines

    E. Ostrea Jr.

Authors
  1. D. Bielawski
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  2. E. Ostrea Jr.
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  3. N. Posecion Jr.
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  4. M. Corrion
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  5. J. Seagraves
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Correspondence to D. Bielawski.

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Bielawski, D., Ostrea, E., Posecion, N. et al. Detection of Several Classes of Pesticides and Metabolites in Meconium by Gas Chromatography-Mass Spectrometry. Chroma 62, 623–629 (2005). https://doi.org/10.1365/s10337-005-0668-7

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  • DOI: https://doi.org/10.1365/s10337-005-0668-7

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