Abstract
Miniaturized sample preparation technique for complex sample matrices has been developed with a polymer-coated fibrous extraction medium. By using extraction cartridge packed longitudinally with polymer-coated fiber into a short PEEK capillary, the extraction efficiency was significantly improved. The extraction cartridge was installed in an injection valve as a sample loop and the on-line coupling with microcolumn liquid chromatography (micro-LC) was demonstrated. This on-line coupled sample preparation/separation system showed a good validity for the analysis of phthalates and tricyclic antidepressant drugs in typical water samples. The lowest limits of quantification for several phthalates and tricyclic antidepressants (TCA) drugs were less than 1 ng mL−1. The effect of polymeric coating on the filament surface on the extraction power was also investigated.
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Acknowledgments.
A part of this research was financially supported by Grant-in-Aid for Young Scientists ((B) No. 15750066) from The Ministry of Education, Culture, Sports, Science and Technology (MEXT). The authors would like to thank to Toyobo Co., Ltd. for the donation of Zylon® fiber.
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Imaizumi, M., Saito, Y., Ban, K. et al. In-Valve Sample Preparation Cartridge Designed for Microcolumn Liquid Chromatography. Chromatographia 60, 619–623 (2004). https://doi.org/10.1365/s10337-004-0428-0
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DOI: https://doi.org/10.1365/s10337-004-0428-0