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Simultaneous Determination of Trimethoprim, Sulfadiazine, Florfenicol and Oxolinic Acid in Surface Water by Liquid Chromatography Tandem Mass Spectrometry

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Abstract

A liquid chromatographic/tandem mass spectrometric method using atmospheric pressure chemical ionisation (LC-APCI-MS-MS) was developed for simultaneous determination of trimethoprim, sulfadiazine, florfenicol and oxolinic acid in surface water. The compounds were extracted by solid phase extraction on a polymeric sorbent. Two transition products were monitored for each compound. The detection capabilities related to the transition products of lowest abundance were 1 ng L−1 for trimethoprim, sulfadiazine and florfenicol and 2 ng L−1 for oxolinic acid. The mean recoveries were 84%, 83%, 96% and 78% at a level of 10 ng L−1. The relative repeatability standard deviations were less than 11% at a level of 10 ng L−1.

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Authors and Affiliations

  1. Steins Laboratorium, Ladelundvej 85, 6650, Brørup, Denmark

    L. K. Sørensen & T. H. Elbæk

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  1. L. K. Sørensen
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  2. T. H. Elbæk
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Correspondence to L. K. Sørensen.

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Sørensen, L., Elbæk, T. Simultaneous Determination of Trimethoprim, Sulfadiazine, Florfenicol and Oxolinic Acid in Surface Water by Liquid Chromatography Tandem Mass Spectrometry. Chromatographia 60, 287–291 (2004). https://doi.org/10.1365/s10337-004-0383-9

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  • DOI: https://doi.org/10.1365/s10337-004-0383-9

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