Abstract
An isocratic liquid chromatographic method for determination of acetaminophen (AMP), caffeine (CAF), chlorphenamine maleate (CPM) and guaiacol glyceryl ether (GGE) in a compound cold formulation is described. Separation and quantitation were achieved on a Diamonsil C18 column using a binary mixture of methanol and 1.5% aqueous acetic acid (55: 45, v/v, pH 3.6) as mobile phase delivered at 0.4 mL min−1. Single wavelength detection was at 220 nm for all four drugs and the run time was < 10 min. The linearity, accuracy and precision of the method were found to be acceptable over the concentration ranges: 16.0–127.8 μg mL−1 for AMP, 6.0–48.2 μg mL−1 for CAF, 5.0–40.0 μg mL−1 for CPM and 10.1–80.6 μg mL−1 for GGE.
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Qi, M., Wang, P. & Chen, J. LC Method for the Determination of Multiple Components in a Compound Cold Formulation. Chromatographia 60, 105–108 (2004). https://doi.org/10.1365/s10337-004-0340-7
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DOI: https://doi.org/10.1365/s10337-004-0340-7