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Receptor-Based Screening Assays: New Perspectives in Anti-Doping Control

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Abstract

The so-called “growth promoters”, steroid hormones and β-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for screening purposes, on immunoassays. These methods are often too specific to allow an effective multianalyte control. To develop more efficient assays, the use of hormonal receptors as detection tools (receptor-based binding assays and cell-based assays) is proposed. Receptor-based assays represent useful tools in screening of hormonal residues in food, but they could also be applied in doping control (to detect “new” hormonal substances). Furthermore, these assays could be used to monitor the human exposure to endocrine disruptors.

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Authors and Affiliations

  1. Laboratory of Analysis of Foodstuffs of Animal Origin, Centre of Analysis of Residues in Traces (CART), University of Liège, 4000 Liège, (Sart-Tilman), Belgium

    M.-L. Scippo, S. Danyi, V. Helbo & G. Maghuin-Rogister

  2. Laboratory of Molecular Biology and Genetic Engineering, Centre of Analysis of Residues in Traces (CART), University of Liège, 4000 Liège, (Sart-Tilman), Belgium

    P. Willemsen, M. Muller & J. Martial

Authors
  1. M.-L. Scippo
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  2. P. Willemsen
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  3. S. Danyi
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  4. V. Helbo
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  5. M. Muller
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  6. J. Martial
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  7. G. Maghuin-Rogister
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Corresponding author

Correspondence to G. Maghuin-Rogister.

Additional information

In Honour of Professor Edward Houghton: A Celebration of 30 Years in Racing Chemisty

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Scippo, ML., Willemsen, P., Danyi, S. et al. Receptor-Based Screening Assays: New Perspectives in Anti-Doping Control. Chromatographia 59 (Suppl 1), S23–S27 (2004). https://doi.org/10.1365/s10337-004-0235-7

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  • DOI: https://doi.org/10.1365/s10337-004-0235-7

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