Abstract
A QSTAR Pulsar quadrupole time-of-flight mass spectrometer was used for the determination of chlorophenols in surface water samples. The investigated compounds were: 2-chlorophenol; 4-chloro-3-methylphenol; 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol. Each analyte is listed by the US-EPA as a priority pollutant. Sample enrichment of water samples was achieved by a solid-phase extraction procedure, using a Waters Oasis HLB cartridges followed by LC-Tandem-MS. A narrow-bore 2.1-mm-i.d. reversed phase LC C-18 column operating with a mobile phase flow rate of 0.2 mL min−1. was used to separate the analytes. The whole column effluent was diverted to the ion spray interface source. For the determination of the analytes the hybrid quadrupole time-of-flight spectrometer operated in product ion scan acquisition mode. Average recoveries from 2 L samples varied from 91 to 110% and relative standard deviations (RSD) were less than 10% for all samples. The limit of detection (signal-to-noise ratio=3) of the method for the phenols in drinking water samples is less than 10 ng L−1. In real environmental samples, levels of the selected analytes varied from “non-detected” up to 0.5 μg L−1 for pentachlorophenol.
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References
Jensen J (1996) Rev Envirom Contam Toxicol 146:25–32
Wild SR, Harrad SJ, Jones KC (1993) Water Res 271:527–535
De Walle FB, Kalman DA, Dills R, Norman D, Chian ESK, Giabbai M, Ghosal M (1980) Water Sci Technol 14:143–151
US Environmental protection Agency, Environmental and Support Laboratory (1977) Sampling and Analysis Procedure for Screening of Industrial Effluents for Priority Pollutants. Cincinnati, OH
Lee MR, Yeh YC, Hsiang WS, Hwang BH (1998) J Chromatogr A 806:317–325
Di Corcia A, Bellioni A, Madbouly MD, Marchese S (1996) J Chromatogr A 733:383–389
Lee HB, Stokker YD, Chau ASY (1987) J Assoc Off Anal Chem70:1003–1011
Turnes I, Rodrýguez I, Garcýa CM, Cela R (1996) J Chromatogr A 743: 283–292
Harrad SJ, Malloy A, Ali Khan M, Goldfarb TD (1991) Chemosphere 23: 83–92
Wall AJ, Stratton GW (1991) Chemosphere 22:99–107
Barceló D (1988) Chromatographia 25:295–302
Barceló D, Durand G, Vreeken RJ, De Jong GJ, Lingeman H, Brinkman UA (1991) J Chromatogr A 553:311–319
Puig D, Barceló D (1995) Chromatographia 40:435–442
Farran A, Cortina JL, de Pablo J, Barceló D (1990) Anal Chim Acta 234:119–124
Puig D, Barceló D, Silgoner I, Grasserbauer M (1996) J Mass Spectrom 31:1297–1305
Puig D, Barceló D, Silgoner I, Grasserbauer M (1997) Anal Chem 69:2756–2764
Jauregui O, Moyano E, Garcelan M (1997) J Chromatogr A 787:79–88
Sarrion MN, Santos FJ, Moyano E, Garcelan MT (2003) Rapid Commun. Mass Spectrom 17:39–48
Schlossmann J, Ammendola A, Ashman K, Zong X., Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (2000) Nature 404:197–202
Watty A, Neubauer G, Dreger M, Zimmer M, Wilm M, Burden SJ (2000) Proc. Natl. Acad. Sci. USA 97:4585–4599
Hoffmann R, Wachs WO, Berger RG, Kalbitzer HR, Waidelich D, Bayer E, Wagner-Redeker W, Zeppezauer M (1995) Int J Pept Protein Res 45:26–35
Lehmann WD (1999) In: Proceedings of the 32nd Annual Meeting of the German Mass Spectrometry Society. Oldenburg, pp. 112–125
Steen H, Kuster B, Fernandez M, Pandey A, Mann M (2001) Anal Chem 73:1440–1448
Morris HR, Paxton T, Dell A, Langhorne J, Berg M, Bordoli RS, Hoyes J, Bateman RH, (1996) Rapid Commun Mass Spectrom 10:889–896
Parker GA (1991) J AOAC Int 74:868–875
Marchese S, Gentili A, Perret D, D’Ascenzo G, Pastori P (2003) Rapid Commun. Mass Spectrom 17:879–886
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Marchese, S., Gentili, A., Perret, D. et al. Hybrid Quadrupole Time-of-Flight for the Determination of Chlorophenols in Surface Water by Liquid Chromatography-Tandem Mass Spectrometry. Chromatographia 59, 411–417 (2004). https://doi.org/10.1365/s10337-004-0208-x
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DOI: https://doi.org/10.1365/s10337-004-0208-x