Abstract
A curve fitting procedure to optimise liquid-liquid extraction of weakly acid or basic drugs is presented. Data for three drugs are used to exemplify the utility of such an approach, including the determination of unknown pK a values. The potential for using calculated partition coefficients is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brodie BB, Undenfriend S, Baer JE (1947) J Biol Chem 168:299–309
Whelpton R, Curry SH (1976) Solvent extraction applied to fluphenazine and its metabolites. In: Reid E, (eds.), Assay of Drugs and other Trace Compounds in Biological Fluids. North-Holland, Oxford, pp 115–120
Nielsen-Kudsk F (1983) Int J Biomedical Computing 14:95–107
Whelpton R (1989) Trends Pharmacol Sci 10:182–183
Budavari S (1996) (ed.) The Merck Index. 12 ed. Merck & Co. Inc. New Jersey
Sorby DL, Plein EM, Benmaman JD (1966) J Pharm Sci 55:785–787
Green AL (1967) J Pharm Pharmacol 19:10–16
Leo A, Hansch C, Elkins D (1971) Chem Rev 71:525–553
Author information
Authors and Affiliations
Corresponding author
Additional information
Presented at: 15th International Bioanalytical Forum. The Changing Role of Bioanalysis: Discovery to Market, Guildford, UK, July 1, 4, 2003
Rights and permissions
About this article
Cite this article
Whelpton, R. Iterative Least Squares Fitting of pH-Extraction Curves Using an Object-Orientated Language. Chromatographia 59 (Suppl 2), S193–S196 (2004). https://doi.org/10.1365/s10337-003-0119-2
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1365/s10337-003-0119-2