Chromatographia

, Volume 71, Issue 9–10, pp 963–966 | Cite as

GC Quantification of Cyclopropylamine, Diethylamine and Triethylamine in Active Pharmaceutical Ingredients

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Abstract

Gas chromatography with headspace injection technique has been developed for the quantification of diethylamine, triethylamine and cyclopropylamine in active pharmaceutical ingredients. The chromatographic separation is achieved on dimethylpolysiloxane oil coated capillary column with flame ionization detector. GC run time was 15 min employing programmed temperature with split mode headspace injection. The method is validated for specificity, linearity, accuracy, precision, and robustness.

Keywords

Gas chromatography Head space injection Amines 
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Notes

Acknowledgments

The authors wish to thank the management of Hetero Labs Limited for supporting this work and Dr. D.V. Subbarao of Versapharm Inc USA.

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Copyright information

© Vieweg+Teubner Verlag | Springer Fachmedien Wiesbaden GmbH 2010

Authors and Affiliations

  1. 1.Hetero Labs Ltd.HyderabadIndia
  2. 2.Invagen Pharmaceuticals IncHauppaugeUSA
  3. 3.Department of ChemistrySri Krishna Devaraya UniversityAnantapurIndia

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