A Validated RP-LC Method for Advanced Intermediate of Rabeprazole Sodium
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Abstract
The present paper describes the development of a reversed phase liquid chromatographic method for advanced intermediate of rabeprazole sodium (RBS-1) in the presence of its impurities. Successful separation of RBS-1 from the synthetic impurities achieved on a Inertsil ODS3V C18, 150 mm × 4.6 mm column. The developed LC method was validated with respect to linearity, accuracy, precision, specificity and ruggedness. To the best of our knowledge, a validated stability indicating LC method which separates all the impurities disclosed in this investigation was not published elsewhere.
Keywords
Column liquid chromatography Method validation Rabeprazole sulphideNotes
Acknowledgment
The authors would like to thank all the colleagues of the R&D Department, Inogent Laboratories Private Ltd., Hyderabad, India, for their support to carry out this investigation.
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