Abstract
The optical characteristics of four kinds of amino acids (tyrosine, arginine, histidine and glutamine) filled with nitrogen at room temperature were studied by THz time-domain spectroscopy (THz-TDS). Well-resolved absorption and refractive spectrums between 0.1 and 2.8 THz were obtained based on the physical model for extracting the optical parameters of materials in THz range. The results not only fill up the spectra gap of amino acids in far-infrared range, supply data for amino acid molecular identification and conformation analysis, but also demonstrate significantly potential to promote the research and application of biological materials in bio-chemical and medical fields by THz-TDS.
Similar content being viewed by others
References
Mickan, S.P., Zhang, X. C., T-ray sensing and imaging, International Journal of High Speed Electronics and Systems, 2003, 13(2): 601–676.
Shen, Y. C., Upadhya, P. C., Linfield, E. H. et al., Vibrational spectra of nucleosides studied using terahertz time-domain spectroscopy, Vibrational Spectroscopy, 2004, 35: 111–114.
Taday, P. F., Bradley, I. V., Arnone, D. D., Terahertz pulse spectroscopy of biological materials: L-2 glutamic acid, Journal of Biological Physic, 2003, 29: 109–115.
Miyamaru, F., Yamaguchi, M., Hangyo, M. et al., THz-time-domain spectroscopy of amino acids in solid phase, 2003 CLEO’ 03 2–4.
Yu, B., Zeng, F., Torsion vibrational modes of Tryptophan studied by Terahertz time-domain spectroscopy, Biophysical Journal, 2004, 86: 1649–1654.
Timothy, D. D., Richard, G. B., Daniel M M., Material parameter estimation with terahertz time-domain spectroscopy, Journal of the Optical Society of America A: Optics, Image Science, and Vision, 2001, 18(7): 1562–1571.
Duvillaret, L., Garet, F., Coutaz, J. L., Highly precise determination of optical constants and sample thickness in terahertz time-domain spectroscopy, Applied Optics, 1999, 38(2): 409–415.
van Exter, M., Fattinger, C., Grischkowsky, D., Terahertz time-domain spectroscopy of water vapor, Optics Letters, 1989, 14(20): 1128–1130.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Weining, W., Weiwei, Y., Haitao, Y. et al. THz time-domain spectroscopy of amino acids. Chin.Sci.Bull. 50, 1561–1565 (2005). https://doi.org/10.1360/982005-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1360/982005-7