Chinese Science Bulletin

, Volume 50, Issue 8, pp 745–751 | Cite as

Novel layered pesticide slow/controlled release materials—supramolecular structure and slow release property of glyphosate intercalated layered double hydroxides



Two different interlayer structured glyphosate (GLY) intercalated MgAl layered double hydroxides, as novel pesticide slow/controlled release materials, have been synthesized by co-precipitation method under various reaction pH values. The slow/controlled release properties have been tested in Na2CO3 aqueous solution. The release mechanism has been interpreted on the basis of the ion-exchange between the guest GLY anions in the lamellar host and CO32− in the release media, and the diffusion process of GLY anions in the interstice and interlayer of GLY intercalates, i.e. diffusion through the particles, is the rate-limiting step of GLY release process. The GLY intercalate assembled at lower pH, possessing higher interlayer gallery height and vertical monolayered arrangement of guest anions in the interlayer with larger packing density, exhibits better slow release property than that assembled at higher pH. The results reveal that the layered double hydroxides have potential application in the pesticide slow/controlled release area.


layered double hydroxides co-precipitation slow/controlled release materials supramolecular structure glyphosate 


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  1. 1.
    Cavani, F., Trifirb, F., Vaccari, A., Hydrotalcite-type anionic clays: preparation, properties and applications, Catal. Today, 1991, 11: 173–301.CrossRefGoogle Scholar
  2. 2.
    Vaccari, A., Clays and catalysis: a promising future, Appl. Clay Sci., 1999, 14(4): 161–198.CrossRefGoogle Scholar
  3. 3.
    Newman, S. P., Jones, W., Synthesis, characterization and applications of layered double hydroxides containing organic guests, New J. Chem., 1998, 22(2): 105–115.CrossRefGoogle Scholar
  4. 4.
    Tronto, J., Sanchez, K. C., Crepaldi, E. L. et al., Synthesis, characterization and electrochemical study of layered double hydroxides intercalated with 2-thiophenecarboxylate anions, J. Phys. Chem. Solids, 2004, 65: 493–498.CrossRefGoogle Scholar
  5. 5.
    Hu, C. W., Li, D. F., Guo, Y. H. et al., Supermolecular layered double hydroxides, Chinese Sci. Bull., 2001, 46(13): 1061–1066.CrossRefGoogle Scholar
  6. 6.
    Choy, J. H., Jung, J. S., Oh, J. M. et al., Layered double hydroxide as an efficient drug reservoir for folate derivatives, Biomaterials, 2004, 25: 3059–3064.CrossRefGoogle Scholar
  7. 7.
    Khan, A. I., Lei, L., Norquist, A. J. et al., Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide, Chem. Commun., 2001, (22): 2342–2343.Google Scholar
  8. 8.
    Ambrogi, V., Fardella, G., Grandolini, G. et al., Intercalation compounds of hydrotalcite-like anionic clays with anti-inflammatory agents, I. Intercalation and in vitro release of ibuprofen, Int. J. Pharm., 2001, 220(1–2): 23–32.CrossRefGoogle Scholar
  9. 9.
    Ambrogi, V., Fardella, G., Grandolini, al., Intercalation compounds of hydrotalcite-like anionic clays with anti-inflammatory agents, II: uptake of diclofenac for a controlled release formulation, AAPS Pharm. Sci. Tech., 2002, 3(3): article 26.Google Scholar
  10. 10.
    Tronto, J., Reis, M. J., Silvério, F. et al., In vitro release of citrate anions intercalated in magnesium aluminum layered double hydroxides, J. Phys. Chem. Solids, 2004, 65: 475–480.CrossRefGoogle Scholar
  11. 11.
    Hussein, M. Z., Zainal, Z., Yahaya, A. H. et al., Controlled release of a plant growth regulator, a-naphthaleneacetate from the lamella of Zn-A1 layered double hydroxide nanocomposite, J. Control. Release, 2002, 82: 417–427.CrossRefGoogle Scholar
  12. 12.
    Meng, J. H., Zhang, H., Evans, D. G., Duan, X., Studies on assembly and structure of supramolecular glyphosate intercalated magnesium-aluminum layered double hydroxide, Chem. J. Chinese U. (in Chinese), 2003, 24(7): 1315–1319.Google Scholar
  13. 13.
    Sanchez-Martin, M. J., Villa, M. V., Sánchez-Camazano, M., Glyphosate-hydrotalcite interaction as influenced by pH, Clay. Clay Miner., 1999, 47(6): 777–783.CrossRefGoogle Scholar
  14. 14.
    Millange, F., Walton, R. I., O’Hare, D., Time-resolved in situ X-ray diffraction study of the liquid-phase reconstruction of Mg-Alcarbonate hydrotalcite-like compounds, J. Mater. Chem., 2000, 10: 1713–1720.CrossRefGoogle Scholar
  15. 15.
    Xu, Z. P., Zeng, H. C., Abrupt structural transformation in hydrotalcite-like compounds Mg1-xAlx(OH)2(NO3)x nH2O as a continuous function of nitrate anions, J. Phys. Chem. B, 2001, 105: 1743–1749.CrossRefGoogle Scholar
  16. 16.
    Inorganic Chemisty Staff Room of Dalian University of Technology, Inorganic Chemisty (in Chinese), Beijing: Higher Education Press, 1984, 351–351.Google Scholar
  17. 17.
    Dideriksen, K., Stipp, S. L. S., The adsorption of glyphosate and phosphate to goethite: a molecular-scale atomic force microscopy study, Geochim. Cosmochim. Ac., 2003, 67(18): 3313–3327.CrossRefGoogle Scholar
  18. 18.
    Kaliannan, P., Ali, M. M. N., Seethalakshmi, T. et al., Electronic structure and conformation of glyphosate: an ab initio MO study, J. Mol. Struct., 2002, 618: 117–125.Google Scholar
  19. 19.
    Kooli, F., Chisem, I. C., Vucelic, M. et al., Synthesis and properties of terephthalate and benzoate intercalates of Mg-A1 layered double hydroxides possessing varying layer charge, Chem. Mater., 1996, 8: 1969–1977.CrossRefGoogle Scholar
  20. 20.
    Hines, D. R., Solin, S. A., Physical properties of fixed-charge layer double hydroxides, Phys. Rev. B, 2000, 61: 11348–11358.CrossRefGoogle Scholar
  21. 21.
    Mogul, M. G., Akin, H., Hasirci, N. et al., Controlled release of biologically active agents for purposes of agricultural crop management, Resour Conserv Recy, 1996, 16: 289–320.CrossRefGoogle Scholar
  22. 22.
    Bhaskar, R., Murthy, S. R. S., Miglani, B. D., et al., Novel method to evaluate diffusion controlled release of drug from resinate, Int. J. Pharm., 1986, 28: 59–66.CrossRefGoogle Scholar

Copyright information

© Science in China Press 2005

Authors and Affiliations

  1. 1.Ministry of Education Key Laboratory of Science and Technology of Controllable Chemical ReactionsBeijing University of Chemical TechnologyBeijingChina

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