Abstract
A novel method for preparation of magnetic polymer microspheres by spraying suspension polymerization (SSP) was developed. Relatively uniform magnetic poly(methyl methacrylate) microspheres were prepared by the spraying suspension polymerization (SSP) using methyl methacrylate (MMA) as monomer, divinylbenzene (DVB) as cross-linking agent, benzoyl peroxide (BPO) as initiator and polyvinyl alcohol (PVA) as stabilizer in the presence of hydrophobic Fe3O4 magnetic fluid. The microspheres prepared were modified by surface chemical reaction. The magnetic properties and morphology of the microspheres were examined by SEM and VSM respectively. The active functional groups of microspheres were examined by infrared spectra. The results showed that microspheres with saturation magnetization of 16.8 emu/g showed distinct superparamagnetic characteristics and the magnetic microspheres with a size of 10 μm were relatively uniform.
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References
Kronick, P., Gilpin, R. W., Use of superparamagnetic particles for isolation of cells, J. Biochem. Biophy. Methods, 1986, 12: 73–80.
Li, X. H., Sun, Z. H., Synthesis of magnetic polymer micro-spheres and application for immobilization of proteinase of balillus sublitis, J. Appl. Polym. Sci., 1995, 58: 1991–1997.
Abudiab, T., Beitle, R. R., Preparation of magnetic immobilized metal affinity separation media and its use in the isolation of proteins, J. Chromatogr. A, 1998, 795: 211–217.
Josephson, L., Magnetic particles for use in separations, US Patent, 4 672 040, 1987-06-09.
Cupta, P. K., Hung, C. T., Magnetically controlled targeted micro-carrier systems, Life Sci., 1989, 44: 175–186.
Kondo, A., Kamura, H., Higashitahi, K., Development and application of thermosenstive magnetic immunomicrospheres for antibody purification, Appl. Microbiol. Biotechnol., 1994, 41: 99–105.
Horák, D., Magnetic polyglycidylmethacrylate microspheres by dispersion polymerization, J. Polym. Sci., Part A: Polym. Chem., 2001, 39: 3707–3715.
Lee, J., Senna, M., Preparation of monodispersed polystyrene microspheres uniformly coated by magnetite via heterogeneous polymerization, Colloid Polym. Sci., 1995, 273: 76–82.
Liu, X. Q., Guan, Y. P., Xing, J. M. et al., Synthesis and properties of micron-size magnetic polymeric spheres with epoxy group, Chinese J. Chem. Eng., 2003, 11: 731–735.
Daniel, Magnetic polymer latex and preparation process, US Patent, 4 358 388, 1982-11-09.
Ugelstad, J., Ellingsen, T., Berge, A. et al., Magnetic Polymer Particles, PCT Int. Appl., WO Patent, 8 303 920, 1983-11-10.
Liu, X. Q., Liu, H. Z., Xing, J. M. et al., Preparation and characterization of superparamagnetic functional polymeric micro-spheres, China Particuology, 2003, 1: 76–79.
Wu, J. G., Modern Fourier Transform Infrared Spectroscopy Technology and Its Application (in Chinese), Beijing: Literature Press of Science and Technology, 1994, 595–599.
Duan, X. X., Handbook of Applied Fine Organic Synthesis (in Chinese), Beijing: Press of Chemical Industry, 2000, 135–136.
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Yang, C., Guan, Y., Xing, J. et al. Preparation and surface modification of magnetic poly(methyl methacrylate) microspheres. Sc. China Ser. B-Chem. 47, 349–354 (2004). https://doi.org/10.1360/04yb0033
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DOI: https://doi.org/10.1360/04yb0033