Abstract
Rupture of atherosclerotic plaque is the main trigger of acute cardiovascular events, but the mechanism of plaque rupture is still unknown. We have constructed a model describing the motion of the fibrous cap of the plaque using the theory of elastic mechanics and studied the stability of the plaque theoretically. It has shown that plaque rupture is the result of a dynamic interplay between factors intrinsic to the plaque itself and extrinsic factors. We have proposed a new mechanism of plaque rupture, given a new explanation about the nonlinear dynamic progress of atherosclerosis and suggested a method to identify the vulnerable plaques to manage atherosclerosis.
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Su, H., Zhang, M. & Zhang, Y. Mechanical model of vulnerable atherosclerotic plaque rupture. Sci China Ser G: Phy & Ast 47, 452–462 (2004). https://doi.org/10.1360/03yw0267
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DOI: https://doi.org/10.1360/03yw0267