Abstract
Experimental backgrounds of ectopic discharges were made by i.p. administrating of 4-aninopyriding (4-AP), a K+ channel blocker, or anisodamine, a muscarinic receptor blocker, in CCI rats, and the sympathetic sprouting in the dorsal root ganglia (DRG) as well as the heat-hyperalgesia was observed. It was demonstrated that the increased ectopic discharges induced by 4-AP promote sympathetic sprouting in the DRG and a greater number of sympathetic basket cells were developed, causing exacerbation of heat-hyperalgesia in CCI rats. On the contrary, the sympathetic sprouting in the DRG and heat-hyperalgesia are evidently diminished after anisodamine injection. Our results suggest that ectopic discharges may be an immediate factor in triggering sympathetic sprouting in DRG following peripheral nerve injury.
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Dong, C., Xie, Z., Fan, J. et al. Ectopic discharges trigger sympathetic sprouting in rat dorsal root ganglia following peripheral nerve injury. Sci. China Ser. C.-Life Sci. 45, 191–200 (2002). https://doi.org/10.1360/02yc9022
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DOI: https://doi.org/10.1360/02yc9022