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Prediction on amphiphilicity of hypocrellin derivatives

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Abstract

Hypocrellins are most suitable for photodynamic therapy (PDT) of the diseases occurring in the superficial layer, such as microvascular diseases, because of their special absorption spectral properties. However, hypocrellins and most of their derivatives are basically lipophilic, while the hydrophilic derivatives lose the PDT activity in vivo. Therefore, the key problem for practical application of PDT of microvascular diseases focuses on finding the derivatives which possess optimized amphiphilicity. Herein, we developed a theoretical method to estimate the amphiphilicity of a molecule by the calculated average polarity. Compared with the experimentally measured results, the method is proved to be applicable. Based on the computation and available experimental results, it can be concluded that the derivative must have the polarities around 0.22 for optimized amphiphilicity.

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Authors and Affiliations

  1. Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 100101, Beijing, China

    Xie Jie, Jianghua Ma & Jingquan Zhao

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  1. Xie Jie
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  2. Jianghua Ma
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  3. Jingquan Zhao
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Correspondence to Jingquan Zhao.

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Xie, J., Ma, J. & Zhao, J. Prediction on amphiphilicity of hypocrellin derivatives. Sc. China Ser. B-Chem. 45, 251–256 (2002). https://doi.org/10.1360/02yb9033

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  • DOI: https://doi.org/10.1360/02yb9033

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