, Volume 43, Issue 1, pp 165–183 | Cite as

Measurement of cumulative physiological dysregulation in an older population

  • Christopher L. SeplakiEmail author
  • Noreen Goldman
  • Maxine Weinstein
  • Yu-Hsuan Lin


The allostatic load framework postulates that an important pathway connecting the social environment with health involves biological responses to stressful stimuli and the subsequent dysregulation of interrelated physiological systems. We formulate a new measure for cumulative physiological dysregulation using a grade of membership model estimated with biodemographic data from a national sample of older Taiwanese persons. We investigate associations between the measure and physical, psychological, and cognitive function. The results provide insights into the relationships between a set of biological profiles and various health outcomes, identify limitations of earlier approaches, and underscore next steps in the development of improved formulations of physiological dysregulation.


Ordinary Little Square Allostatic Load Primary Mediator Pure Type Medical Exam 
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Copyright information

© Population Association of America 2006

Authors and Affiliations

  • Christopher L. Seplaki
    • 1
    Email author
  • Noreen Goldman
    • 1
  • Maxine Weinstein
    • 2
  • Yu-Hsuan Lin
    • 3
  1. 1.Office of Population ResearchPrinceton UniversityUSA
  2. 2.Center for Population and HealthGeorgetown UniversityUSA
  3. 3.Department of HealthBureau of Health Promotion, Population and Health Research CenterTaichungTaiwan

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