Environmental Health and Preventive Medicine

, Volume 12, Issue 5, pp 217–219 | Cite as

Negative results ofumu genotoxicity test of fluorotelomer alcohols and perfluorinated alkyl acids

  • Yoshimitsu Oda
  • Shoji Nakayama
  • Kouji H. Harada
  • Akio Koizumi
Short Communication

Abstract

Objectives

Recently, perfluorooctanoate (PFOA) has been ubiquitously detected in the environment as well as in human serum. Fluorotelomer alcohols (FTOHs), a precursor of PFOA, undergo biodegradation via several metabolic routes which leads to formation of various biodegradation products. The degradation of FTOHs produces an α,β-unsaturated aldehyde that seems possibly to be electrophilic and may react with cellular macromolecules including DNA.

Methods

We investigated the genotoxicity of three FTOHs (6∶2 FTOH, 8∶2 FTOH and 10∶2 FTOH), PFOA and perfluorooctane sulfonate (PFOS) using theumu test.

Results

The FTOHs, PFOA and PFOS showed no significant increases in β-galactosidase activity at 0–1000 μM in the absence of S9 mix. The results were unchanged by the metabolic activation with S9 mix.

Conclusion

The genotoxicities of FTOHs, PFOA or PFOS are not detectable using the present method, suggesting that they are unlikely mutagens.

Key words

perfluorooctane sulfonate perfluorooctanoic acid fluorotelomer alcohols genotoxicity umu test 

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Copyright information

© Japanese Society of Hygiene 2007

Authors and Affiliations

  • Yoshimitsu Oda
    • 1
  • Shoji Nakayama
    • 2
  • Kouji H. Harada
    • 2
  • Akio Koizumi
    • 2
  1. 1.Osaka Prefectural Institute of Public HealthOsakaJapan
  2. 2.Department of Health and Environmental SciencesKyoto University Graduate School of MedicineKyotoJapan

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