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Intra-Patient Heterogeneity in Micro-satellite-stable Colorectal Metastases: Does Immunotherapy Have a Role in Colorectal Peritoneal Metastases?

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Acknowledgment

This study was supported by the RAD project.

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Author notes

  1. M. B. Mirza and P. Marincola Smith have contributed equally to this work.

Authors and Affiliations

  1. Division of Surgical Oncology and Endocrine Surgery, Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

    M. B. Mirza MD, P. Marincola Smith MD, PhD & K. Idrees MD, MSCI, MMHC, FACS

  2. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA

    Y. Wang PhD & Y. Xu PhD

  3. Division of Otolaryngology, Head and Neck Surgery, Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

    A. Naveed MD

  4. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    M. K. Washington MD, PhD

Authors
  1. M. B. Mirza MD
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  2. P. Marincola Smith MD, PhD
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  3. Y. Wang PhD
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  4. A. Naveed MD
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  5. M. K. Washington MD, PhD
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  6. Y. Xu PhD
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  7. K. Idrees MD, MSCI, MMHC, FACS
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Contributions

All the authors listed have made a substantial, direct, and intellectual contribution to the work, especially in the comprehensive genetic and immunophenotypic analysis of CPMs from two treatment-naïve patients with MSS-CRC. Each author has participated sufficiently in the work to take public responsibility for appropriate portions of the content, in accordance with the guidelines set by the International Committee of Medical Journal Editors (ICMJE).

Corresponding author

Correspondence to K. Idrees MD, MSCI, MMHC, FACS.

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Disclosure

All authors declare that they have no competing interests, financial or otherwise, related to the current work. All the sources of funding for the research are disclosed, and any affiliations or involvement (either competitive or amiable) in any organization or entity with a direct financial interest in the subject matter or materials discussed in the manuscript are disclosed.

Consent to Publication

The submitted work is original and provides a comprehensive analysis of the genetic and immunophenotypic landscape of CPM in mCRC patients. It has not been published elsewhere and is not under consideration by any other publication. All data, figures, and tables are original, and any similarities with existing work are cited appropriately.

Ethical Approval

The research was conducted after IRB approval was obtained. All procedures involving analysis of patient specimens were performed in compliance with relevant laws and institutional guidelines. The study adhered to ethical guidelines, ensuring the confidentiality and rights of the patients involved.

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Mirza, M.B., Smith, P.M., Wang, Y. et al. Intra-Patient Heterogeneity in Micro-satellite-stable Colorectal Metastases: Does Immunotherapy Have a Role in Colorectal Peritoneal Metastases?. Ann Surg Oncol 31, 1440–1443 (2024). https://doi.org/10.1245/s10434-023-14694-8

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  • DOI: https://doi.org/10.1245/s10434-023-14694-8

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