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Top Colorectal Articles from 2021 to Inform Your Cancer Practice

  • Colorectal Cancer
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Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Multimodality treatment for locally advanced rectal cancer is the standard of care. Treatments include surgery, radiation, and chemotherapy, with medical therapies now being favored in the neoadjuvant setting. Various regimens continue to be studied and defined in prospective randomized trials. The PRODIGE 23 and RAPIDO trials showed improved disease-free survival and pathologic complete response rates for split chemotherapy/radiation treatment and short-course radiation with consolidation chemotherapy, respectively; both compared with traditional neoadjuvant long course chemoradiation, surgery, and adjuvant chemotherapy. Furthermore, new regimens are yielding a higher rate of complete clinical response, allowing for non-operative management. Circulating tumor DNA provides a potential novel option for monitoring response to treatment and rectal cancer surveillance. This manuscript summarizes some of the key clinical trials and studies that are defining clinical practice.

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA

    Matthew F. Kalady MD

  2. Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA

    Scott R. Steele MD, MBA

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  1. Matthew F. Kalady MD
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  2. Scott R. Steele MD, MBA
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Correspondence to Matthew F. Kalady MD.

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Kalady, M.F., Steele, S.R. Top Colorectal Articles from 2021 to Inform Your Cancer Practice. Ann Surg Oncol 30, 5489–5494 (2023). https://doi.org/10.1245/s10434-023-13651-9

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