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Colonoscopy-Assisted Laparoscopic Wedge Resection for the Treatment of Suspected T1 Colon Cancer

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Local en bloc resection of pT1 colon cancer has been gaining acceptance during the last few years. In the absence of histological risk factors, the risk of lymph-node metastases (LNM) is negligible and does not outweigh the morbidity and mortality of an oncologic resection. Colonoscopy-assisted laparoscopic wedge resection (CAL-WR) has proved to be an effective and safe technique for removing complex benign polyps. The role of CAL-WR for the primary resection of suspected T1 colon cancer has to be established.

Methods

This retrospective study aimed to determine the radicality and safety of CAL-WR as a local en bloc resection technique for a suspected T1 colon cancer. Therefore, the study identified patients in whom high-grade dysplasia or a T1 colon carcinoma was suspected based on histology and/or macroscopic assessment, requiring an en bloc resection.

Results

The study analyzed 57 patients who underwent CAL-WR for a suspected macroscopic polyp or polyps with biopsy-proven high-grade dysplasia or T1 colon carcinoma. For 27 of these 57 patients, a pT1 colon carcinoma was diagnosed at pathologic examination after CAL-WR. Histological risk factors for LNM were present in three cases, and 70% showed deep submucosal invasion (Sm2/Sm3). For patients with pT1 colon carcinoma, an overall R0-resection rate of 88.9% was achieved. A minor complication was noted in one patient (1.8%).

Conclusions

The CAL-WR procedure is an effective and safe technique for suspected high-grade dysplasia or T1-colon carcinoma. It may fill the gap for tumors that are macroscopic suspected for deep submucosal invasion, providing more patients an organ-preserving treatment option.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Isala, Zwolle, The Netherlands

    Julia Hanevelt MD, Jelle F. Huisman MD & Wouter H. de Vos tot Nederveen Cappel MD, PhD

  2. Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands

    Leon M. G. Moons MD, PhD

  3. Department of Surgery, Isala, Zwolle, The Netherlands

    Judith E. K. R. Hentzen MD, PhD, Tess M. Wemeijer MD & Henderik L. van Westreenen MD, PhD

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  1. Julia Hanevelt MD
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  2. Leon M. G. Moons MD, PhD
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Correspondence to Julia Hanevelt MD.

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Hanevelt, J., Moons, L.M.G., Hentzen, J.E.K.R. et al. Colonoscopy-Assisted Laparoscopic Wedge Resection for the Treatment of Suspected T1 Colon Cancer. Ann Surg Oncol 30, 2058–2065 (2023). https://doi.org/10.1245/s10434-022-12973-4

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