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Health-Related Quality of Life Following Simultaneous Resection for Synchronous Colorectal Cancer Liver Metastases

  • Global Health Services Research
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Introduction

Up to 25% of colorectal cancer patients present with synchronous liver metastases that can be treated with two operations or a single ‘simultaneous’ operation. Morbidity and mortality appear similar between approaches, however changes in health-related quality-of-life following simultaneous resection are not well reported.

Methods

A prospective, feasibility trial for simultaneous resection of synchronous colorectal liver metastases was conducted. Patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 and LMC21 at baseline (preoperatively), and 4 and 12 weeks postoperatively. Week 4 and 12 scores were compared with baseline using t-tests. Minimally important clinical differences were considered as a 10-point difference from baseline.

Results

C30 and QLQ-LMC21 were completed at baseline, 4 weeks, and 12 weeks by 39 (95%), 35 (85%) and 34 (83%) patients, and 39 (95%), 33 (80%) and 33 (80%) patients, respectively; 79% and 75% had at least one MICD according to QLQ-C30 at 4 and 12 weeks. At 4 weeks, physical functioning (mean difference (MD) − 11.9%, p = 0.002), role functioning (MD − 23.6, p = 0.007), and pain (MD + 19.7, p = 0.017) had significant worsening from baseline. At 12 weeks postoperatively, role functioning (MD − 19.7, p = 0.011) and fatigue (MD + 14.3, p = 0.03) were the only domains that remained significantly worse. By 12 weeks, pain and physical functioning had returned to baseline. There were no major demographic differences among those with and without an MICD at 12 weeks.

Conclusions

Simultaneous resection of colorectal liver metastases led to clinically significant worsening fatigue and role functioning that persisted at 12 weeks post-surgery.

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Authors and Affiliations

  1. Department of Surgery, McMaster University, Hamilton, ON, Canada

    C. D. Griffiths MD, MBA, V. Francescutti MD, MSc & P. E. Serrano MD, MPH

  2. Department of Surgery, University of Toronto, Toronto, ON, Canada

    P. Karanicolas MD, PhD & S. Gallinger MD, MSc

  3. Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    P. Karanicolas MD, PhD

  4. Department of Surgery, University Health Network, Toronto, ON, Canada

    S. Gallinger MD, MSc

  5. Department of Surgery, Memorial Sloan Kettering Cancer Centre, New York, NY, USA

    A. D. Wei MDCM, MSc

  6. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada

    P. E. Serrano MD, MPH

  7. Juravinski Hospital, Hamilton, ON, Canada

    P. E. Serrano MD, MPH

Authors
  1. C. D. Griffiths MD, MBA
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  2. P. Karanicolas MD, PhD
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  3. S. Gallinger MD, MSc
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  4. A. D. Wei MDCM, MSc
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  5. V. Francescutti MD, MSc
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  6. P. E. Serrano MD, MPH
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Correspondence to P. E. Serrano MD, MPH.

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Griffiths, C.D., Karanicolas, P., Gallinger, S. et al. Health-Related Quality of Life Following Simultaneous Resection for Synchronous Colorectal Cancer Liver Metastases. Ann Surg Oncol 30, 1331–1338 (2023). https://doi.org/10.1245/s10434-022-12696-6

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  • DOI: https://doi.org/10.1245/s10434-022-12696-6

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