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Impact of Screening Mammography on Treatment in Young Women Diagnosed with Breast Cancer

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

There is little data exploring the impact of screening mammography on subsequent treatment in the 40–49-year age group with breast cancer. We sought to assess the association between frequency of mammography in young women and extent of surgery and chemotherapy required.

Methods

An IRB-approved retrospective review was performed of patients diagnosed with breast cancer between ages 40 and 49 years from 1 January 2010 to 19 November 2018 within a single health system. Patients were grouped based on last screening 1–24 months prior to diagnosis (1–24 group), > 25 months prior to diagnosis (> 25 group), never screened, and > 25+ never screened (combination group). Multivariate logistic regression models were used to assess for associations between screening intervals and tumor and nodal stage, chemotherapy use, and extent of surgery.

Results

Of 869 patients included for analysis, 20% were never screened, 60% screened 1–24 months, and 19% screened > 25 months prior to diagnosis. Compared with the 1–24 months group, the never-screened group, > 25 months group, and combined group were more likely to receive chemotherapy. The never-screened and combined groups were more likely to undergo mastectomy and/or axillary lymph node dissection. Of patients undergoing upfront surgery, the > 25 months and combined groups were more likely to receive adjuvant chemotherapy, while the never-screened and combined groups were more likely to have nodal disease.

Conclusion

Our findings support the initiation of screening mammography at age 40 years to reduce the risk of aggressive treatments for newly diagnosed breast cancers in this group.

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Acknowledgements

The authors wish to acknowledge the support of the Biostatistics Shared Resource Facility, Icahn School of Medicine at Mount Sinai, and NCI Cancer Center Support Grant P30 CA196521-01.

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Authors and Affiliations

  1. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Shkala Karzai MD, Elisa Port MD, Cleo Siderides BA, Christopher Valente MD, Soojin Ahn MD, Erin Moshier MS, Meng Ru MS, Kereeti Pisapati MS, Ronald Couri BA, Laurie Margolies MD, Hank Schmidt MD, PhD & Sarah Cate MD

Authors
  1. Shkala Karzai MD
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  2. Elisa Port MD
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  3. Cleo Siderides BA
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  4. Christopher Valente MD
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  5. Soojin Ahn MD
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  6. Erin Moshier MS
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  7. Meng Ru MS
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  8. Kereeti Pisapati MS
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  9. Ronald Couri BA
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  12. Sarah Cate MD
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Contributions

All authors listed made substantial contributions to the manuscript presented here. E.P., S.A., and S.C. developed the study question and contributed to revising and final approval of the work. S.K., M.R., E.M., and C.S. contributed to data analysis, reporting, and drafting the work. K.P., R.C., and C.V. contributed to data analysis and reporting. H.S. and L.M. contributed to revision of the work.

Corresponding author

Correspondence to Sarah Cate MD.

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The authors have no conflicts of interest to disclose.

Ethical approval

The study was approved by the institutional review board of the Icahn School of Medicine at Mount Sinai.

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Karzai, S., Port, E., Siderides, C. et al. Impact of Screening Mammography on Treatment in Young Women Diagnosed with Breast Cancer. Ann Surg Oncol 29, 4116–4124 (2022). https://doi.org/10.1245/s10434-022-11581-6

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  • DOI: https://doi.org/10.1245/s10434-022-11581-6

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