Abstract
Background
Recurrence rates of intrahepatic cholangiocarcinoma (iCCA) after curative hepatectomy are as high as 50% to 70%, and about half of these recurrences occur within 2 years. This systematic review aims to define prognostic factors (PFs) for early recurrence (ER, within 24 months) and 24-month disease-free survival (DFS) after curative-intent iCCA resections.
Methods
Systematic searching was performed from database inception to 14 January 2021. Duplicate independent review and data extraction were performed. Data on 13 predefined PFs were collected. Meta-analysis was performed on PFs for ER and summarized using forest plots. The Quality in Prognostic Factor Studies tool was used for risk-of-bias assessment.
Results
The study enrolled 10 studies comprising 4158 patients during an accrual period ranging from 1990 to 2016. In the risk-of-bias assessment of patients who experienced ER after curative-intent iCCA resection, six studies were rated as low risk and four as moderate risk (49.6%; 95% confidence interval [CI], 49.2–50.0). Nine studies were pooled for meta-analysis. Of the postoperative PFs, multiple tumors, microvascular invasion, macrovascular invasion, lymph node metastasis, and R1 resection were associated with an increased hazard for ER or a reduced 24-month DFS, and the opposite was observed for receipt of adjuvant chemo/radiation therapy. Of the preoperative factors, cirrhosis, sex, HBV status were not associated with ER or 24-month DFS.
Conclusion
The findings from this systematic review could allow for improved surveillance, prognostication, and treatment decision-making for patients with resectable iCCAs. Further well-designed prospective studies are needed to explore prognostic factors for iCCA ER with a focus on preoperative variables.
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Acknowledgment
We acknowledge the Hold’em for Life Fellowship program for providing salary support for Woo Jin Choi.
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Appendices
Appendix 1
Search Strategy
Medline-Ovid MEDLINE(R) 1946 to January 14, 2021
# | Searches | Results |
|---|---|---|
1 | cholangiocarcinoma/ or klatskin tumor/ | 9616 |
2 | (Adenoma, Bile Duct/ or Bile Duct Neoplasms/) and Liver Neoplasms/ | 3518 |
3 | cholangiocarcinom*.mp. | 12771 |
4 | cholangiocellular carcinoma*.mp. | 796 |
5 | Klatskin*.mp. | 927 |
6 | Common Hepatic Duct/ and (Adenocarcinoma/ or Adenoma, Bile Duct/ or Bile Duct Neoplasms/) | 825 |
7 | or/1-6 [ Cholangiocarcinoma ] | 15490 |
8 | exp bile ducts, intrahepatic/ or bile canaliculi/ | 11545 |
9 | intrahepatic*.mp. | 35575 |
10 | intra-hepatic*.mp. | 962 |
11 | or/8-10 [ Intrahepatic ] | 37008 |
12 | 7 and 11 [ Cholangiocarcinoma + Intrahepatic ] | 7493 |
13 | Recurrence/ | 185969 |
14 | Neoplasm Recurrence, Local/ | 120657 |
15 | recidiv*.mp. | 11368 |
16 | recur*.mp. | 651873 |
17 | recur*.kw. | 11331 |
18 | recrudescen*.mp,kw. | 3241 |
19 | relaps*.mp,kw. | 165638 |
20 | Disease-Free Survival/ | 75806 |
21 | Survival Analysis/ | 138074 |
22 | Survival Rate/ | 177115 |
23 | (progress* adj2 surviv*).mp,kw. | 42960 |
24 | (diseas* adj2 surviv*).mp,kw. | 106691 |
25 | (surviv* adj2 analy*).mp,kw. | 170692 |
26 | (rate? adj2 surviv*).mp,kw. | 281829 |
27 | "cancer free".mp,kw. | 3685 |
28 | exp Neoplasm Metastasis/ | 206891 |
29 | sc.fs. [secondary] | 161616 |
30 | Micrometast*.mp,kw. | 6329 |
31 | Micro-metast*.mp,kw. | 462 |
32 | metasta*.mp,kw. | 506242 |
33 | secondary.mp,kw. | 827441 |
34 | metastasectom*.mp,kw. | 2302 |
35 | or/13-34 [ Recurrence & related terms ] | 2110846 |
36 | 12 and 35 [ Cholangiocarcinoma + Intrahepatic + Recurrence ] | 3552 |
37 | exp Surgical Procedures, Operative/ | 3199040 |
38 | su.fs. | 2017941 |
39 | (surgery or surgeries or surgical* or operat* or laparoscop* or resect* or reresect* or reoperat*).mp. | 3428085 |
40 | cholangio*ectom*.mp. | 3 |
41 | cholangio*ostom*.mp. | 184 |
42 | hepatectom*.mp. | 36041 |
43 | hepato*ostom*.mp. | 318 |
44 | metastectom*.mp. | 78 |
45 | necrosectom*.mp. | 836 |
46 | posthepatectom*.mp. | 390 |
47 | post-hepatectom*.mp. | 405 |
48 | hemihepatectom*.mp. | 877 |
49 | hemi-hepatectom*.mp. | 103 |
50 | lobectom*.mp. | 17503 |
51 | (minimal* adj3 invasiv*).mp. | 70591 |
52 | Hepatectomy/ | 30410 |
53 | (excis* adj8 (liver? or hepat*)).mp. | 2664 |
54 | transplant*.mp. | 720204 |
55 | graft*.mp. | 362724 |
56 | allograft*.mp. | 67427 |
57 | or/37-56 [ Surgery ] | 4915416 |
58 | 36 and 57 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Surgery ] | 2580 |
59 | (early or earlier or earliest).mp. | 1626807 |
60 | (time adj3 recur*).mp. | 9111 |
61 | (time adj3 relaps*).mp. | 4394 |
62 | timing.mp. | 116605 |
63 | Time Factors/ | 1199216 |
64 | or/59-63 [ Early[NA1] ] | 2760065 |
65 | 58 and 64 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Surgery + Early ] | 539 |
66 | (animal or animals or ape or apes or baboon or baboons or bat or bats or bird or birds or boar or boars or bonobo or bonobos or bovine or camel or camels or canine or canines or cat or cats or cattle or chicken or chickens or chimpanzee or chimpanzees or dog or dogs or dromedary or dromedaries or duck or ducks or equine or equines or feline or felines or ferret or ferrets or frog or frogs or fowl or fowls or goat or goats or hare or hares or hen or hens or horse or horses or lamb or lambs or livestock or macaque or macaques or mandrill or mandrills or mice or mink or minks or monkey or monkeys or mouse or murine or ovine or pig or pigs or piglet or piglets or poultry or porcine or orangutan or orangutans or rabbit or rabbits or rat or rats or rodent or rodents or sheep or swine or tamarin or tamarins or tiger or tigers or veterinary or veterinarian or veterinarians or waterfowl or waterfowls or weasel or weasels or veterinar* or (veterinar* or fish or shellfish)).ti,jw. | 2553335 |
67 | 65 not 66 | 536 |
68 | (human* or patient? or man or mankind or men or women or woman or adult*).ti,jw. | 3466040 |
69 | 65 and 68 | 104 |
70 | limit 65 to humans | 534 |
71 | 67 or 69 or 70 | 536 |
72 | remove duplicates from 71 | 536 |
73 | (adolescence or adolescent or adolescents or babies or baby or boy or boys or child or childhood or children or childrens or children's or fetus or fetal or foetus or foetal or girl or girls or infancy or infant or infants or neonatal or neonatally or neonate or neonates or newborn or newborns or paediatric or paediatrician or paediatricians or paediatrics or pediatric or pediatrician or pediatricians or pediatrics or preschool* or teen or teenage or teenagers or teens or toddler or toddlers or tween* or youth or youths).ti,jw. | 1662392 |
74 | 72 not 73 | 533 |
75 | (elder* or senior? or aged or adult* or man or men or woman or women).ti,jw. | 847112 |
76 | 72 and 75 | 6 |
77 | limit 72 to ("all infant (birth to 23 months)" or "all child (0 to 18 years)" or "newborn infant (birth to 1 month)" or "infant (1 to 23 months)" or "preschool child (2 to 5 years)" or "child (6 to 12 years)" or "adolescent (13 to 18 years)") | 21 |
78 | 72 not 77 | 515 |
79 | limit 72 to ("all adult (19 plus years)" or "young adult (19 to 24 years)" or "adult (19 to 44 years)" or "young adult and adult (19-24 and 19-44)" or "middle age (45 to 64 years)" or "middle aged (45 plus years)" or "all aged (65 and over)" or "aged (80 and over)") | 422 |
80 | 74 or 76 or 78 or 79 | 536 |
81 | remove duplicates from 80 | 536 |
Medline In-Process- Ovid MEDLINE(R) Epub Ahead of Print and In-Process & Other Non-Indexed Citations January 14, 2021
# | Searches | Results |
|---|---|---|
1 | cholangiocarcinoma/ or klatskin tumor/ | 0 |
2 | (Adenoma, Bile Duct/ or Bile Duct Neoplasms/) and Liver Neoplasms/ | 0 |
3 | cholangiocarcinom*.mp. | 3000 |
4 | cholangiocellular carcinoma*.mp. | 109 |
5 | Klatskin*.mp. | 112 |
6 | Common Hepatic Duct/ and (Adenocarcinoma/ or Adenoma, Bile Duct/ or Bile Duct Neoplasms/) | 0 |
7 | or/1-6 [ Cholangiocarcinoma ] | 3101 |
8 | exp bile ducts, intrahepatic/ or bile canaliculi/ | 0 |
9 | intrahepatic*.mp. | 3905 |
10 | intra-hepatic*.mp. | 161 |
11 | or/8-10 [ Intrahepatic ] | 4027 |
12 | 7 and 11 [ Cholangiocarcinoma + Intrahepatic ] | 1101 |
13 | Recurrence/ | 0 |
14 | Neoplasm Recurrence, Local/ | 0 |
15 | recidiv*.mp. | 968 |
16 | recur*.mp. | 92562 |
17 | recur*.kw. | 7338 |
18 | recrudescen*.mp,kw. | 266 |
19 | relaps*.mp,kw. | 26222 |
20 | Disease-Free Survival/ | 0 |
21 | Survival Analysis/ | 0 |
22 | Survival Rate/ | 0 |
23 | (progress* adj2 surviv*).mp,kw. | 11425 |
24 | (diseas* adj2 surviv*).mp,kw. | 9092 |
25 | (surviv* adj2 analy*).mp,kw. | 10312 |
26 | (rate? adj2 surviv*).mp,kw. | 23166 |
27 | "cancer free".mp,kw. | 620 |
28 | exp Neoplasm Metastasis/ | 0 |
29 | sc.fs. [secondary] | 0 |
30 | Micrometast*.mp,kw. | 622 |
31 | Micro-metast*.mp,kw. | 103 |
32 | metasta*.mp,kw. | 91858 |
33 | secondary.mp,kw. | 119859 |
34 | metastasectom*.mp,kw. | 561 |
35 | or/13-34 [ Recurrence & related terms ] | 328784 |
36 | 12 and 35 [ Cholangiocarcinoma + Intrahepatic + Recurrence ] | 569 |
37 | exp Surgical Procedures, Operative/ | 0 |
38 | su.fs. | 0 |
39 | (surgery or surgeries or surgical* or operat* or laparoscop* or resect* or reresect* or reoperat*).mp. | 437712 |
40 | cholangio*ectom*.mp. | 3 |
41 | cholangio*ostom*.mp. | 16 |
42 | hepatectom*.mp. | 3023 |
43 | hepato*ostom*.mp. | 42 |
44 | metastectom*.mp. | 13 |
45 | necrosectom*.mp. | 222 |
46 | posthepatectom*.mp. | 65 |
47 | post-hepatectom*.mp. | 143 |
48 | hemihepatectom*.mp. | 151 |
49 | hemi-hepatectom*.mp. | 38 |
50 | lobectom*.mp. | 3225 |
51 | (minimal* adj3 invasiv*).mp. | 16842 |
52 | Hepatectomy/ | 0 |
53 | (excis* adj8 (liver? or hepat*)).mp. | 306 |
54 | transplant*.mp. | 52344 |
55 | graft*.mp. | 42896 |
56 | allograft*.mp. | 6497 |
57 | or/37-56 [ Surgery ] | 505846 |
58 | 36 and 57 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Surgery ] | 351 |
59 | (early or earlier or earliest).mp. | 250030 |
60 | (time adj3 recur*).mp. | 1709 |
61 | (time adj3 relaps*).mp. | 547 |
62 | timing.mp. | 23076 |
63 | Time Factors/ | 1 |
64 | or/59-63 [ Early ] | 269508 |
65 | 58 and 64 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Surgery + Early ] | 52 |
66 | (animal or animals or ape or apes or baboon or baboons or bat or bats or bird or birds or boar or boars or bonobo or bonobos or bovine or camel or camels or canine or canines or cat or cats or cattle or chicken or chickens or chimpanzee or chimpanzees or dog or dogs or dromedary or dromedaries or duck or ducks or equine or equines or feline or felines or ferret or ferrets or frog or frogs or fowl or fowls or goat or goats or hare or hares or hen or hens or horse or horses or lamb or lambs or livestock or macaque or macaques or mandrill or mandrills or mice or mink or minks or monkey or monkeys or mouse or murine or ovine or pig or pigs or piglet or piglets or poultry or porcine or orangutan or orangutans or rabbit or rabbits or rat or rats or rodent or rodents or sheep or swine or tamarin or tamarins or tiger or tigers or veterinary or veterinarian or veterinarians or waterfowl or waterfowls or weasel or weasels or veterinar* or (veterinar* or fish or shellfish)).ti,jw. | 196970 |
67 | 65 not 66 | 52 |
68 | (human* or patient? or man or mankind or men or women or woman or adult*).ti,jw. | 451435 |
69 | 65 and 68 | 13 |
70 | limit 65 to humans | 0 |
71 | 67 or 69 or 70 | 52 |
72 | (adolescence or adolescent or adolescents or babies or baby or boy or boys or child or childhood or children or childrens or children's or fetus or fetal or foetus or foetal or girl or girls or infancy or infant or infants or neonatal or neonatally or neonate or neonates or newborn or newborns or paediatric or paediatrician or paediatricians or paediatrics or pediatric or pediatrician or pediatricians or pediatrics or preschool* or teen or teenage or teenagers or teens or toddler or toddlers or tween* or youth or youths).ti,jw. | 198467 |
73 | 71 not 72 | 52 |
74 | remove duplicates from 73 | 51 |
Embase- Embase Classic+Embase 1947 to 2021 January 14
# | Searches | Results |
|---|---|---|
1 | exp bile duct carcinoma/ [ Embase ] | 29808 |
2 | cholangiocarcinoma/ or klatskin tumor/ | 15968 |
3 | (Adenoma, Bile Duct/ or Bile Duct Neoplasms/) and Liver Neoplasms/ | 367 |
4 | cholangiocarcinom*.mp. | 22936 |
5 | cholangiocellular carcinoma*.mp. | 1410 |
6 | Klatskin*.mp. | 1296 |
7 | Common Hepatic Duct/ and (Adenocarcinoma/ or Adenoma, Bile Duct/ or Bile Duct Neoplasms/) | 58 |
8 | or/1-7 [ Cholangiocarcinoma ] | 33529 |
9 | exp intrahepatic bile duct/ [ Embase ] | 9512 |
10 | exp common hepatic duct/ [ Embase ] | 1215 |
11 | exp bile ducts, intrahepatic/ or bile canaliculi/ | 9512 |
12 | intrahepatic*.mp. | 55646 |
13 | intra-hepatic*.mp. | 2331 |
14 | or/9-13 [ Intrahepatic ] | 58236 |
15 | 8 and 14 [ Cholangiocarcinoma + Intrahepatic ] | 9378 |
16 | cancer recurrence/ [ Embase ] | 198371 |
17 | Recurrence/ | 162127 |
18 | Neoplasm Recurrence, Local/ | 32106 |
19 | recidiv*.mp. | 17123 |
20 | recur*.mp. | 1142400 |
21 | recur*.kw. | 56619 |
22 | recrudescen*.mp,kw. | 4874 |
23 | relaps*.mp,kw. | 389938 |
24 | Disease-Free Survival/ | 88302 |
25 | Survival Analysis/ | 25936 |
26 | Survival Rate/ | 260984 |
27 | (progress* adj2 surviv*).mp,kw. | 138109 |
28 | (diseas* adj2 surviv*).mp,kw. | 128345 |
29 | (surviv* adj2 analy*).mp,kw. | 100629 |
30 | (rate? adj2 surviv*).mp,kw. | 379520 |
31 | "cancer free".mp,kw. | 6448 |
32 | exp Neoplasm Metastasis/ | 696854 |
33 | metastasis/ [ Embase ] | 323890 |
34 | Micrometast*.mp,kw. | 12148 |
35 | Micro-metast*.mp,kw. | 1172 |
36 | metasta*.mp,kw. | 970685 |
37 | secondary.mp,kw. | 1102064 |
38 | metastasectom*.mp,kw. | 4010 |
39 | or/16-38 [ Recurrence & related terms ] | 3505147 |
40 | 15 and 39 [ Cholangiocarcinoma + Intrahepatic + Recurrence ] | 5112 |
41 | exp surgery/ [ Embase ] | 5462884 |
42 | exp liver surgery/ [ Embase ] | 182092 |
43 | exp liver resection/ [ Embase ] | 63024 |
44 | hemihepatectomy/ [ Embase ] | 2041 |
45 | liver lobectomy/ or partial hepatectomy/ [ Embase ] | 11095 |
46 | exp Surgical Procedures, Operative/ | 5462884 |
47 | su.fs. | 2218425 |
48 | (surgery or surgeries or surgical* or operat* or laparoscop* or resect* or reresect* or reoperat*).mp. | 5528735 |
49 | cholangio*ectom*.mp. | 8 |
50 | cholangio*ostom*.mp. | 296 |
51 | hepatectom*.mp. | 37160 |
52 | hepato*ostom*.mp. | 4679 |
53 | metastasectom*.mp. | 4010 |
54 | metastectom*.mp. | 246 |
55 | necrosectom*.mp. | 2249 |
56 | posthepatectom*.mp. | 704 |
57 | post-hepatectom*.mp. | 931 |
58 | hemihepatectom*.mp. | 2561 |
59 | hemi-hepatectom*.mp. | 245 |
60 | lobectom*.mp. | 48019 |
61 | (minimal* adj3 invasiv*).mp. | 136671 |
62 | Hepatectomy/ | 46903 |
63 | (excis* adj8 (liver? or hepat*)).mp. | 3790 |
64 | transplant*.mp. | 1017819 |
65 | graft*.mp. | 760033 |
66 | allograft*.mp. | 124364 |
67 | or/41-66 [ Surgery ] | 7542943 |
68 | 40 and 67 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Surgery ] | 3780 |
69 | (early or earlier or earliest).mp. | 2652920 |
70 | (time adj3 recur*).mp. | 18762 |
71 | (time adj3 relaps*).mp. | 10271 |
72 | time factor/ [ Embase ] | 38147 |
73 | Time Factors/ | 30856 |
74 | or/69-73 [ Early ] | 2709595 |
75 | 68 and 74 [ Cholangiocarcinoma + Intrahepatic + Recurrence + Prediction + Surgery + Early ] | 540 |
76 | (animal or animals or ape or apes or baboon or baboons or bat or bats or bird or birds or boar or boars or bonobo or bonobos or bovine or camel or camels or canine or canines or cat or cats or cattle or chicken or chickens or chimpanzee or chimpanzees or dog or dogs or dromedary or dromedaries or duck or ducks or equine or equines or feline or felines or ferret or ferrets or frog or frogs or fowl or fowls or goat or goats or hare or hares or hen or hens or horse or horses or lamb or lambs or livestock or macaque or macaques or mandrill or mandrills or mice or mink or minks or monkey or monkeys or mouse or murine or ovine or pig or pigs or piglet or piglets or poultry or porcine or orangutan or orangutans or rabbit or rabbits or rat or rats or rodent or rodents or sheep or swine or tamarin or tamarins or tiger or tigers or veterinary or veterinarian or veterinarians or waterfowl or waterfowls or weasel or weasels or veterinar* or (veterinar* or fish or shellfish)).ti,jw. | 3311878 |
77 | 75 not 76 | 536 |
78 | (human* or patient? or man or mankind or men or women or woman or adult*).ti,jw. | 5338789 |
79 | 75 and 78 | 100 |
80 | limit 75 to human | 516 |
81 | 77 or 79 or 80 [ Limited to human ] | 537 |
82 | limit 81 to (conference abstracts or (books or chapter or conference abstract or "conference review") or (book or book series or conference proceeding)) | 194 |
83 | 81 not 82 | 343 |
84 | 81 not (conference abstract or conference review).pt. | 345 |
85 | 83 or 84 | 345 |
86 | remove duplicates from 85 | 336 |
CCTR-Cochrane Central Register of Controlled Trials 2014 to Present
# | Searches | Results |
|---|---|---|
1 | cholangiocarcinoma/ or klatskin tumor/ | 223 |
2 | (Adenoma, Bile Duct/ or Bile Duct Neoplasms/) and Liver Neoplasms/ | 34 |
3 | cholangiocarcinom*.mp. | 795 |
4 | cholangiocellular carcinoma*.mp. | 21 |
5 | Klatskin*.mp. | 36 |
6 | or/1-5 [ Cholangiocarcinoma ] | 831 |
7 | Common Hepatic Duct/ and (Adenocarcinoma/ or Adenoma, Bile Duct/ or Bile Duct Neoplasms/) | 1 |
8 | exp Bile Ducts, Intrahepatic/ [ Embase ] | 39 |
9 | exp Hepatic Duct, Common/ [ Embase ] | 7 |
10 | exp bile ducts, intrahepatic/ or bile canaliculi/ | 39 |
11 | intrahepatic*.mp. | 1727 |
12 | intra-hepatic*.mp. | 116 |
13 | or/7-12 [ Intrahepatic ] | 1834 |
14 | 6 and 13 [ Intrahepatic Cholangiocarcinoma ] | 284 |
15 | cancer recurrence/ [ Embase ] | 0 |
16 | Recurrence/ | 11985 |
17 | Neoplasm Recurrence, Local/ | 4203 |
18 | recidiv*.mp. | 908 |
19 | recur*.mp. | 77896 |
20 | recur*.kw. | 15913 |
21 | recrudescen*.mp,kw. | 514 |
22 | relaps*.mp,kw. | 42923 |
23 | Disease-Free Survival/ | 6895 |
24 | Survival Analysis/ | 8241 |
25 | Survival Rate/ | 10321 |
26 | (progress* adj2 surviv*).mp,kw. | 27597 |
27 | (diseas* adj2 surviv*).mp,kw. | 19179 |
28 | (surviv* adj2 analy*).mp,kw. | 17193 |
29 | (rate? adj2 surviv*).mp,kw. | 29945 |
30 | "cancer free".mp,kw. | 356 |
31 | exp Neoplasm Metastasis/ | 5231 |
32 | metastasis/ [ Embase ] | 3235 |
33 | Micrometast*.mp,kw. | 423 |
34 | Micro-metast*.mp,kw. | 81 |
35 | metasta*.mp,kw. | 46561 |
36 | secondary.mp,kw. | 267998 |
37 | metastasectom*.mp,kw. | 201 |
38 | or/15-37 [ Recurrence & related terms ] | 401976 |
39 | 14 and 38 [ Intrahepatic Cholangiocarcinoma + Recurrence ] | 221 |
40 | exp General Surgery/ [ Embase ] | 354 |
41 | hemihepatectomy/ [ Embase ] | 0 |
42 | liver lobectomy/ or partial hepatectomy/ [ Embase ] | 0 |
43 | exp Surgical Procedures, Operative/ | 117422 |
44 | su.fs. | 58330 |
45 | (surgery or surgeries or surgical* or operat* or laparoscop* or resect* or reresect* or reoperat*).mp. | 290301 |
46 | cholangio*ectom*.mp. | 0 |
47 | cholangio*ostom*.mp. | 8 |
48 | hepatectom*.mp. | 1602 |
49 | hepato*ostom*.mp. | 66 |
50 | metastectom*.mp. | 11 |
51 | necrosectom*.mp. | 102 |
52 | posthepatectom*.mp. | 25 |
53 | post-hepatectom*.mp. | 35 |
54 | hemihepatectom*.mp. | 66 |
55 | hemi-hepatectom*.mp. | 9 |
56 | lobectom*.mp. | 1595 |
57 | (minimal* adj3 invasiv*).mp. | 7047 |
58 | Hepatectomy/ | 614 |
59 | (excis* adj8 (liver? or hepat*)).mp. | 59 |
60 | transplant*.mp. | 39642 |
61 | graft*.mp. | 32696 |
62 | allograft*.mp. | 4754 |
63 | or/40-62 [ Surgery ] | 371428 |
64 | 39 and 63 [ Intrahepatic Cholangiocarcinoma + Recurrence + Surgery ] | 143 |
65 | (early or earlier or earliest).mp. | 143194 |
66 | (time adj3 recur*).mp. | 3139 |
67 | (time adj3 relaps*).mp. | 2760 |
68 | time factor/ [ Embase ] | 65250 |
69 | Time Factors/ | 65250 |
70 | or/65-69 [ Early ] | 204401 |
71 | 64 and 70 [ Intrahepatic Cholangiocarcinoma + Recurrence + Surgery + Early ] | 23 |
72 | (animal or animals or ape or apes or baboon or baboons or bat or bats or bird or birds or boar or boars or bonobo or bonobos or bovine or camel or camels or canine or canines or cat or cats or cattle or chicken or chickens or chimpanzee or chimpanzees or dog or dogs or dromedary or dromedaries or duck or ducks or equine or equines or feline or felines or ferret or ferrets or frog or frogs or fowl or fowls or goat or goats or hare or hares or hen or hens or horse or horses or lamb or lambs or livestock or macaque or macaques or mandrill or mandrills or mice or mink or minks or monkey or monkeys or mouse or murine or ovine or pig or pigs or piglet or piglets or poultry or porcine or orangutan or orangutans or rabbit or rabbits or rat or rats or rodent or rodents or sheep or swine or tamarin or tamarins or tiger or tigers or veterinary or veterinarian or veterinarians or waterfowl or waterfowls or weasel or weasels or veterinar* or (veterinar* or fish or shellfish)).ti,jw. | 10906 |
73 | 71 not 72 | 23 |
74 | (human* or patient? or man or mankind or men or women or woman or adult*).ti,jw. | 517172 |
75 | 71 and 74 | 8 |
76 | 73 or 75 | 23 |
77 | (abstract or book or book article or book book or book note or "book review" or book series article or book series article in press or book series chapter or book series conference paper or book series letter or "book series review" or book series short survey or chapter or conference abstract or conference abstract placebo controlled partly blinded crossover study in 12 sle patients or conference proceeding or "conference review" or journal conference abstract or "journal conference review").pt. | 182126 |
78 | 76 not 77 | 17 |
79 | remove duplicates from 78 | 16 |
CDSR-Cochrane Database of Systematic Reviews 2005 to Present
# | Searches | Results |
|---|---|---|
1 | cholangiocarcinom*.ti,ab. | 5 |
2 | cholangiocellular carcinoma*.ti,ab. | 0 |
3 | (bile duct? adj2 carcinoma*).ti,ab. | 0 |
4 | Klatskin*.ti,ab. | 0 |
5 | or/1-4 [ Cholangiocarcinoma ] | 5 |
6 | intrahepatic*.ti,ab. | 13 |
7 | intra-hepatic*.ti,ab. | 2 |
8 | or/6-7 [ Intrahepatic ] | 15 |
9 | 5 and 8 [ Cholangiocarcinoma + Intrahepatic ] | 2 |
10 | recidiv*.ti,ab. | 8 |
11 | recur*.ti,ab. | 662 |
12 | recur*.kw. | 317 |
13 | recrudescen*.ti,ab. | 0 |
14 | relaps*.ti,ab. | 354 |
15 | (progress* adj2 surviv*).ti,ab. | 120 |
16 | (diseas* adj2 surviv*).ti,ab. | 64 |
17 | (surviv* adj2 analy*).ti,ab. | 23 |
18 | (rate? adj2 surviv*).ti,ab. | 79 |
19 | "cancer free".ti,ab. | 1 |
20 | Micrometast*.ti,ab. | 1 |
21 | Micro-metast*.ti,ab. | 1 |
22 | metasta*.ti,ab. | 192 |
23 | secondary.ti,ab. | 1871 |
24 | metastasectom*.ti,ab. | 0 |
25 | or/1-24 [ Recurrence ] | 2871 |
26 | 9 and 25 [ Intrahepatic Cholangiocarcinoma + Recurrence ] | 2 |
27 | (surgery or surgeries or surgical* or operat* or laparoscop* or resect* or reresect* or reoperat*).ti,ab. | 2047 |
28 | cholangio*ectom*.ti,ab. | 0 |
29 | cholangio*ostom*.ti,ab. | 0 |
30 | hepatectom*.ti,ab. | 3 |
31 | hepato*ostom*.ti,ab. | 0 |
32 | metastectom*.ti,ab. | 0 |
33 | necrosectom*.ti,ab. | 2 |
34 | posthepatectom*.ti,ab. | 0 |
35 | post-hepatectom*.ti,ab. | 0 |
36 | hemihepatectom*.ti,ab. | 0 |
37 | hemi-hepatectom*.ti,ab. | 0 |
38 | lobectom*.ti,ab. | 5 |
39 | (minimal* adj3 invasiv*).ti,ab. | 63 |
40 | (excis* adj8 (liver? or hepat*)).ti,ab. | 0 |
41 | transplant*.ti,ab. | 314 |
42 | graft*.ti,ab. | 167 |
43 | allograft*.ti,ab. | 18 |
44 | or/27-43 [ Surgery ] | 2363 |
45 | 26 and 44 [ Intrahepatic Cholangiocarcinoma + Recurrence + Surgery ] | 2 |
46 | (early or earlier or earliest).ti,ab. | 1195 |
47 | (time adj3 factor*).ti,ab. | 4 |
48 | (time adj3 recur*).ti,ab. | 31 |
49 | (time adj3 relaps*).ti,ab. | 16 |
50 | or/46-49 [ Early ] | 1234 |
51 | 45 and 50 [ Intrahepatic Cholangiocarcinoma + Recurrence + Surgery + Early ] | 1 |
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Choi, W.J., Williams, P.J., Claasen, M.P.A.W. et al. Systematic Review and Meta-Analysis of Prognostic Factors for Early Recurrence in Intrahepatic Cholangiocarcinoma After Curative-Intent Resection. Ann Surg Oncol 29, 4337–4353 (2022). https://doi.org/10.1245/s10434-022-11463-x
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DOI: https://doi.org/10.1245/s10434-022-11463-x