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Delayed Gastric Emptying After Multivisceral Resection for Retroperitoneal Sarcoma

Annals of Surgical Oncology volume 29, pages 3264–3270 (2022)Cite this article

Abstract

Introduction

Delayed gastric emptying (DGE) is a common complication in surgery, but incidence and relevance following multivisceral resection are unknown.

Methods

Data from 100 consecutive patients treated for primary retroperitoneal sarcoma (RPS) were analyzed from our institutional prospectively maintained database from January 2019 to April 2020. DGE severity was graded according to the International Study Group of Pancreatic Surgery and classified as primary or secondary to other complications. The primary outcome was incidence and grade of clinically relevant DGE (grades B–C). Secondary outcomes were correlation with patient, tumor, and treatment characteristics, and non-DGE morbidity [Clavien-Dindo (CD) grade ≥ 3].

Results

Forty-two patients developed DGE and 28 had clinically relevant DGE. DGE was primary in 10 patients and secondary in 18 patients; the most common associated complications were: infections (11/18, 61.1%), pancreatic leak (7/18, 38.9%), bleeding (6/18, 33.3%), and bowel leak (6/18, 33.3%). DGE was related to longer length of hospital stay (P < 0.001), ICU admission (P = 0.004), ICU length of stay (P = 0.001), postoperative complications (CD \(\ge\) 3 in 14/28 in DGE patients vs 11/72 in no-DGE; P = 0.04), and re-operation (P = 0.03). With multivariate analysis, the independent risk factors for DGE were patient comorbidities (OR 1.05; 95% CI 1.01–1.1; P = 0.04) and tumor size (OR 1.05; 95% CI 1.0–1.1; P = 0.02).

Discussion

Following multivisceral resection, DGE is a clinically relevant event that can be caused by an underlying complication. Prompt diagnosis and treatment of both DGE and any underlying complications led to full recovery in all cases.

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Fig. 1

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Authors and Affiliations

  1. Sarcoma Service, Department of Surgery, IRCCS Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Marco Baia MD, Sandro Pasquali MD, PhD, Catherine Sarre-Lazcano MD, Carlo Abatini MD, Stefano Piero Bernardo Cioffi MD, Alessandro Gronchi MD & Marco Fiore MD, FACS

  2. Ospedale Galmarini di Tradate - ASST Settelaghi, Varese, Tradate, Italy

    Lorenzo Conti MD

  3. Clinical Nutritional Service, IRCCS Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Serena Della Valle MD, Amanda Casirati MD & Cecilia Gavazzi MD

  4. Department of Radiology, IRCCS Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Giorgio Greco MD & Raffaella Vigorito MD

  5. Anesthesiology Department, IRCCS Fondazione Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Paolo Proto MD

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  1. Marco Baia MD
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  2. Lorenzo Conti MD
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  4. Catherine Sarre-Lazcano MD
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  12. Cecilia Gavazzi MD
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  13. Alessandro Gronchi MD
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  14. Marco Fiore MD, FACS
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Correspondence to Marco Fiore MD, FACS.

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Baia, M., Conti, L., Pasquali, S. et al. Delayed Gastric Emptying After Multivisceral Resection for Retroperitoneal Sarcoma. Ann Surg Oncol 29, 3264–3270 (2022). https://doi.org/10.1245/s10434-021-11154-z

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  • DOI: https://doi.org/10.1245/s10434-021-11154-z