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Table 2 Multivariate Cox regression analysis of the variables considered for the adjusted base model

From: Prognostic Performance of Alternative Lymph Node Classification Systems for Patients with Medullary Thyroid Cancer: A Single Center Cohort Study

  All patients Non–metastatic patients (M0)
Risk factor HR (95% CI) p-value HR (95% CI) p-value
Age     
Age<50 1.00 (reference) 0.029 1.00 (reference) 0.025
Age≥50 2.58 (1.10-5.80) 6.90 (1.27-37.38)  
Gender     
Male 1.00 (reference) 0.759 1.00 (reference) 0.706
Female 1.11 (0.57-2.14) 1.26 (0.38-5.00)  
T stage     
T3 + T4 1.00 (reference) 0.235 1.00 (reference) 0.381
T1 + T2 0.65 (0.32-1.33) 1.89 (0.45-7.90)  
MEN syndrome     
Yes 1.00 (reference) 0.790 1.00 (reference) 0.374
No 1.15 (0.41-3.27) 2.19 (0.39-12.40)  
Genetic status     
Known 1.00 (reference) 0.144 1.00 (reference) 0.304
Unknown 2.05 (0.78-5.35) 2.48 (0.44-13.96)  
Tumor multifocality     
Yes 1.00 (reference) 0.087 1.00 (reference) 0.222
No 0.41 (0.15-1.14) 0.33 (0.05-1.97)  
M stage     
M0 1.00 (reference) <0.001 N/A
M1 4.74 (2.26-9.95)